2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is in our sights, headlined by a Thursday night clash between the Lions and the Bills in Buffalo.

Here are the lines for every Week 2 matchup at bet365 Sportsbook as of Sept. 18. 

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Lions 31, Bills 41

Spread: Bills -4.5 (BUF covers)
O/U: 54.5 (Over hits)

Panthers @ Falcons

Spread: Panthers -2.5
Moneyline: Falcons +125, Panthers -150
O/U: 43.5

Bengals @ Texans

Spread: Texans -2.5
Moneyline: Texans -150, Bengals +125
O/U: 46.5

Browns @ Buccaneers

Spread: Bucs -8.5
Moneyline: Bucs -425, Browns +325
O/U: 41.5

Packers @ Jets

Spread: Packers -3.5
Moneyline: Packers -190, Jets +160
O/U: 44.5

Vikings @ Bears

Spread: Bears -4.5
Moneyline: Bears -225, Vikings +185
O/U: 48.5

Saints @ Ravens

Spread: Ravens -8.5
Moneyline: Ravens -425, Saints +325
O/U: 46.5

Eagles @ Titans 

Spread: Eagles -7
Moneyline: Eagles -340, Titans +270
O/U: 39.5

Steelers @ Patriots

Spread: Patriots -5.5
Moneyline: Patriots -245, Steelers +200
O/U: 41.5

Jaguars @ Broncos

Spread: Broncos -2.5
Moneyline: Broncos -150, Jaguars +125
O/U: 45.5

Raiders @ Chargers

Spread: Chargers -6.5
Moneyline: Chargers -300, Raiders +240
O/U: 43.5

Dolphins @ 49ers

Spread: 49ers -13.5
Moneyline: 49ers -1000, Dolphins +650
O/U: 45.5

Seahawks @ Cardinals 

Spread: Seahawks -3.5
Moneyline: Seahawks -205, Cardinals +170
O/U: 41.5

Commanders @ Cowboys

Spread: Cowboys -4.5
Moneyline: Cowboys -210, Commanders +175
O/U: 50.5

Colts @ Chiefs

Spread: Chiefs -6.5
Moneyline: Chiefs -300, Colts +240
O/U: 46.5

Giants @ Rams

Spread: Rams -7.5
Moneyline: Rams -350, Giants +275
O/U: 48.5