MATCHUP ODDS
SPREAD
TO WIN
TOTAL
Detroit Lions
DET
Buffalo Bills
BUF
CHANCE TO WIN
Team to win likelihood based on moneyline
DET 39%
+144
BUF 61%
-171
SPREAD
The Bills must win by more than 3 points to cover the spread
+3.0
DET
-3.0
BUF
SPREAD BREAKDOWN
While the vast majority of bets favor the Lions, 64% of the money is on the Bills.
TEAM TO WIN
A bet of $100 would win $244 total if the Lions win and a bet of $171 would win $271 total if the Bills win
+144
DET
-171
BUF
TEAM TO WIN BREAKDOWN
While the overwhelming majority of bets favor the Bills, only 68% of the money is on the Bills.
TOTAL
The combined final score of both teams is set at 51.5
-113
OVER 51.5
-107
UNDER 51.5
TOTAL BREAKDOWN
Bets and money are in the vast majority towards the Over.
FOX FACTS
10
INSIGHT
The Bills had recorded 24 rushing touchdowns in the red zone, the most in the NFL for the 2025 regular season.
INSIGHT
With 2,422 yards after catch, the Lions led the NFL for the 2025 regular season.
INSIGHT
For the 2025 regular season, the Bills led yards in the fourth quarter in the NFL with 1,793.
PLAYER NEWS
Ty Johnson BUF #26 · RB
Johnson (hamstring) is questionable for Sunday's game at Houston, Joe Buscaglia of The Athletic reports.
Tom Kennedy DET #85 · WR
The Lions signed Kennedy from their practice squad to their active roster Thursday.
T.J. Sanders BUF #98 · DL
Sanders (knee) did not participate at practice Thursday.
STANDINGS
FOLLOW YOUR FAVORITES ADD MORE
Follow your favorite leagues, teams and players to personalize your FOX Sports experience.
Detroit Lions
Buffalo Bills
EVENT INFO
Highmark Stadium
Orchard Park, NY
Sep 18, 2026
FOX SPORTS™, SPEED™, SPEED.COM™ & © 2026 Fox Media LLC
and Fox Sports Interactive Media, LLC. All rights reserved. Use of this
website (including any and all parts and components) constitutes your
acceptance of these
Terms of Use and Privacy Policy | Advertising Choices | 
Your Privacy Choices | Closed Captioning 
Your Privacy Choices | Closed Captioning