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Buffalo Bills vs. Houston Texans - News: Nov 21, 2025

Bills
7-4
7-4
19
FINAL
23
6-5
Spencer Brown - Might go on injured reserve Head coach Sean McDermott told reporters Friday that Brown (shoulder) is a candidate to be placed on injured reserve, Joe Buscaglia of The Athletic reports.
Impact Maddy Glab of the Bills' official site reports that Brown suffered a shoulder injury during the Bills' 23-19 loss to the Texans on Thursday. Ryan Van Demark would be the top candidate to start at right tackle if Brown were to be sidelined for an extended period of time.
NOVEMBER 22, 2025 • ROTOWIRE
Terrel Bernard - Candidate for injured reserve Head coach Sean McDermott said Friday that Bernard (elbow) is a candidate to be placed on injured reserve, Joe Buscaglia of The Athletic reports.
Impact Bernard suffered an elbow injury during the Bills' 23-19 loss to the Texans on Thursday, which is severe enough for him to be considered for a stint on IR. He'll continue to undergo further tests to evaluate the extent of his injury, but he's facing a significant absence, which opens the door for Joe Andreessen or Shaq Thompson to step into a starting role at linebacker alongside Matt Milano and Dorian Williams.
NOVEMBER 22, 2025 • ROTOWIRE
Maxwell Hairston - Placed in concussion protocol Hairston was placed in the concussion protocol Friday, Maddy Glab of the Bills' official site reports.
Impact Hairston apparently sustained the concussion in Thursday night's loss to the Texans. He'll have 10 days to try and get ready for Buffalo's Week 13 contest with the Steelers. Since making his season debut in Week 8, Hairston has produced three tackles (two solo) and three pass breakups, including two interceptions, on 58 percent of the defensive snaps across five contests.
NOVEMBER 22, 2025 • ROTOWIRE
Texans HC DeMeco Ryans makes stance on C.J. Stroud crystal clear as Davis Mills' performance raises major doubts around QB1 Davis Mills has been impressive on the field as C.J. Stroud's replacement in the past three games.
NOVEMBER 22, 2025 • SPORTSKEEDA.COM
Sean McDermott provides injury updates after Week 12 and how the team is moving forward Updates from One Bills Drive Friday afternoon as the Bills recap Week 12 and move forward to Week 13.
NOVEMBER 22, 2025 • BUFFALOBILLS.COM
Patriots' Division Rival Loses Several Players In Disastrous Thursday Night Loss The Buffalo Bills suffered several injuries in Thursday night's disastrous primetime loss to the Houston Texans.
NOVEMBER 22, 2025 • NESN.COM
How Will Anderson Jr. Is Taking the Texans' Player-Driven Defense to Another Level At the start of the offseason every year, or just when he needs to use it, there’s a picture that Texans defensive coordinator Matt Burke wi...
NOVEMBER 22, 2025 • SI.COM

FOX FACTS

3
MILESTONE
James Cook has reached 1,000 rushing yards in the 2025 season. This is his 3rd time reaching 1,000 rushing yards in a single season and the last time he did so was in the 2024 season. Heading into today, only 1 other player has reached 1,000 rushing yards this season.
MILESTONE
Danielle Hunter has reached 10 defensive sacks in the 2025 season. This is his 7th time reaching 10 defensive sacks in a single season and the last time he did so was in the 2024 season. Heading into today, only 2 other players have reached 10 defensive sacks this season.
MILESTONE
James Cook III has passed Travis Henry for sole possession of 7th on the Bills all-time rushing touchdowns list with 28.
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EVENT INFO

NRG Stadium
NRG Stadium
Houston, TX
Nov 21, 2025
70,451
3 Hours 11 Minutes