Hodge suffered a non-contact lower right leg injury early in the second half of Villanova's loss to St. John's on Saturday, the Associated Press reports.
Lewis posted 20 points (8-14 FG, 2-8 3Pt, 2-3 FT), two rebounds, four assists and one steal in 35 minutes during Wednesday's 82-73 victory over Butler.
Hodge notched 10 points (3-7 FG, 2-6 3Pt, 2-3 FT), six rebounds, one assist and one block over 36 minutes during Tuesday's 92-89 OT victory over Xavier.
Perkins posted 17 points (6-15 FG, 1-6 3Pt, 4-5 FT), three rebounds, one block and two steals over 37 minutes during Tuesday's 92-89 OT win over Xavier.
Lewis closed with 21 points (9-18 FG, 0-4 3Pt, 3-6 FT), seven rebounds, six assists and four steals in 38 minutes during Tuesday's 92-89 OT win over Xavier.