The Biggest NFL Upsets in Week 4 - 2025

Which underdogs pulled off an upset in Week 4 of the 2025 NFL season? Below, we take a look at who beat the odds last week.

Read more about last week's NFL games on FOX Sports!

NFL Week 4's Biggest Upsets

Giants 21, Chargers 18

• Spread: Chargers -6
• Total: Under (43.5)
• Moneyline: Chargers -300, Giants +240

Jaguars 26, 49ers 21

• Spread: 49ers -3
• Total: Over (45.5)
• Moneyline: 49ers -175, Jaguars +145

Chiefs 37, Ravens 20

• Spread: Ravens -2.5
• Total: Over (48.5)
• Moneyline: Ravens -150, Chiefs +125

Steelers 24, Vikings 21

• Spread: Vikings -2.5
• Total: Over (41)
• Moneyline: Vikings -150, Steelers +125

Bears 25, Raiders 24

• Spread: Raiders -1.5
• Total: Over (48)
• Moneyline: Raiders -125, Bears +105

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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