Lions vs. Giants 2025 Prediction, Odds, Picks - Nov 23

Having lost one straight, the New York Giants (2-9) will play the Detroit Lions (6-4). The Lions are big favorites (-13.5). The expected point total for the matchup is set at 51.5.

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Lions vs. Giants Odds & Betting Lines

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Lions vs. Giants Prediction & Pick

• Pick ATS: Lions (-13.5)
  
• Pick OU: Under (51.5)
  
• Prediction: Lions 32 - Giants 18

How to Watch Detroit vs. New York

• Game date: Sunday, November 23, 2025
• Time: 1 p.m. ET
• Venue: Ford Field
• Location: Detroit, Michigan
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Lions vs. Giants Recent Matchups

• Detroit owns a 3-0 record against New York in their last three matchups.
• New York has been outpaced by 32 points in its last three tilts against Detroit.

Detroit Betting Info

• Detroit has six wins in 10 games versus the spread this season.
• Detroit contests this year have eclipsed the over/under 50% of the time (five times in 10 games with a set point total).
• When playing as the moneyline favorite, the Lions are 5-1 (winning 83.3% of the time).
• The Lions have an implied win probability, based on the moneyline, of 91.3%.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff has thrown for 2,490 yards (ninth in the NFL), 21 touchdowns (second in the NFL) and four interceptions this year. He is averaging 249 yards per game and 8 per attempt, while completing 69.7% of his passes.
• Jahmyr Gibbs has recorded 732 rushing yards (10th in the NFL) with eight touchdowns (73.2 yards per game through 10 games). His 5.2 yards per attempt rank sixth in the NFL.
• He has caught 37 passes (on 43 targets) for 334 receiving yards with two touchdowns. He's averaging 33.4 receiving yards and 3.7 catches per game.
• In the passing game, Amon-Ra St. Brown, has contributed with 735 receiving yards (eighth in the NFL) and eight touchdowns (second in the NFL) after catching 66 balls (sixth in the NFL) on 94 targets. Per game, he's averaging 73.5 yards and 6.6 receptions over 10 games.
• David Montgomery has rushed for 493 yards, averaging 49.3 yards per game and scoring five touchdowns.
• He's added 15 catches (on 19 targets) for 116 receiving yards with zero touchdowns. He's averaging 11.6 receiving yards and 1.5 receptions per game.

Defense

• On defense, Jack Campbell has 91 tackles, seven TFL, and four sacks in 2025. His tackle total leads the Lions and is sixth in the NFL.
• Aidan Hutchinson has 21 tackles, seven TFL, and 7.5 sacks this season.
• Brian Branch has recorded 52 tackles, five TFL, and 2.5 sacks this year.
• So far this season, Alex Anzalone has 57 tackles, two TFL, 1.5 sacks, and one interception.

New York Betting Info

• New York has covered the spread six times this year (6-5-0).
• This year, New York games have hit the over six times.
• The Giants have won two, or 18.2%, of the 11 games they've played as underdogs this season.
• The moneyline for this contest implies a 12.9% chance of a victory for the Giants.

Giants Stats

New York's Key Players

Offense

• Jaxson Dart is averaging 6.9 passing yards per attempt (21st in the NFL) and 157.4 yards per game this year, completing 62.7% of his passes on the way to 1,417 total yards, 10 touchdowns and three interceptions through nine games.
• Dart has also rushed for seven touchdowns and 317 yards (third on the Giants).
• Wan'Dale Robinson has 57 catches for 638 yards and two receiving touchdowns. He has been targeted 88 times and averages 5.2 receptions per game in 11 games played.
• Theo Johnson has recorded 350 receiving yards and five touchdowns on 36 receptions, while being targeted 55 times this season.
• Tyrone Tracy Jr. has 336 rushing yards (second on the Giants) and one rushing touchdown, while averaging 37.3 yards per game and 4 per carry (31st in the NFL).
• Tracy has also caught 18 passes for 138 yards (seventh on the Giants). He's been targeted 26 times and averages 15.3 yards per game.

Defense

• Brian Burns' 2025 output includes 52 tackles, 17 TFL, and 13 sacks in 11 games. He is fourth on the Giants in tackles.
• Bobby Okereke has totaled one sack in addition to his one TFL and 95 tackles over 11 games.
• Andru Phillips has intercepted two passes on top of 45 tackles, five TFL, and nine passes defended during the 2025 season.
• Dane Belton has totaled 54 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Lions

New York Giants