Jaguars vs. Panthers 2025 Prediction, Odds, Picks - Sep 7

The Jacksonville Jaguars (0-0) are favored by 4.5 points against the Carolina Panthers (0-0) on September 7, 2025, starting at 1 p.m. ET, airing on FOX. The predicted point total for the game is 45.5.

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Jaguars vs. Panthers Odds & Betting Lines

Jaguars vs. Panthers Prediction & Pick

• Pick ATS: Jaguars (-4.5)
  
• Pick OU: Over (45.5)
  
• Prediction: Jaguars 28 - Panthers 20

How to Watch Jacksonville vs. Carolina

• Game date: Sunday, September 7, 2025
• Time: 1 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Jaguars vs. Panthers Recent Matchups

• Jacksonville and Carolina have been evenly matched over their last two meetings, sharing the same 1-1 record.
• Over their last two head-to-head matchups, Jacksonville has scored 53 points, while Carolina has posted 34.

Jacksonville Betting Info

• Jacksonville won 10 games against the spread last season, failing to cover seven times.
• The Jaguars did not lose ATS (1-0) as a 4.5-point favorite or more last season.
• Last season, the combined scoring went over the point total nine times in Jacksonville games.
• The Jaguars won three of the five games they were the moneyline favorite last season (60%).
• Jacksonville played as a moneyline favorite of -205 or shorter in just one game last season, which it won.
• Based on this game's moneyline, the Jaguars' implied win probability is 67.2%.

Jaguars Stats (2024)

Jacksonville's Key Players

Offense

• Last season, Brian Thomas had 87 receptions for 1,282 yards (third in the NFL) with 10 receiving touchdowns (sixth in the NFL). He was targeted 133 times and averaged 5.1 catches per game over 17 games played.
• Trevor Lawrence had 2,045 passing yards, 11 touchdowns and seven interceptions. His completion percentage was 60.6% and he averaged 204.5 yards per game and 7.2 per attempt.
• Lawrence also had three rushing touchdowns and 119 rushing yards.
• Last season over 16 games, Tank Bigsby racked up 766 rushing yards and scored seven rushing touchdowns. He averaged 47.9 yards per game and 4.6 per carry (13th in the NFL).
• Travis Etienne scored two touchdowns on the ground, while running for 558 total yards (3.7 per attempt and 37.2 per game).
• Etienne also caught 39 passes for 254 yards. He was targeted 52 times and averaged 16.9 yards per game.

Defense

• In 2024, Devin Lloyd had 113 tackles, seven TFL, two sacks, and one interception through 16 games.
• Travon Walker had 10.5 sacks to go with 13 TFL and 61 tackles.
• Foyesade Oluokun had one sack in addition to his six TFL, 108 tackles, and one interception.
• Josh Hines-Allen's stat sheet included 45 tackles, 10 TFL, eight sacks, and two passes defended in 16 games

Carolina Betting Info

• Carolina put together an 8-9-0 ATS record last season.
• The Panthers went 8-6 as underdogs of 4.5 points or greater last season.
• A total of 13 of Carolina's games last season hit the over.
• The Panthers were underdogs 16 times last season and won five, or 31.2%, of those games.
• Carolina had a record of 5-9, a 35.7% win rate, when it was set as an underdog of +170 or more by oddsmakers last season.
• The oddsmakers' moneyline implies a 37.0% chance of a victory for the Panthers.

Panthers Stats (2024)

Carolina's Key Players

Offense

• Last year in 15 games, Chuba Hubbard churned out 1,195 yards rushing (eighth in NFL) and scored 10 rushing TDs. He averaged 79.7 yards per game and 4.8 per carry (ninth in NFL).
• In addition to his impact on the ground, Hubbard had 43 catches (on 54 targets) for 171 yards, with one receiving TD. He averaged 11.4 receiving yards per game.
• In 14 games, Bryce Young had 2,403 passing yards, throwing for 15 TDs with nine INTs and completing 60.9% of his passes.
• He tacked on 249 yards rushing, with six TDs on the ground (averaging 17.8 yards per game and 5.8 per carry).
• Rico Dowdle rushed for two TDs last year for the Cowboys and totaled 1,079 yards rushing (67.4 per game and 4.6 per attempt).
• Dowdle helped out in the passing game, picking up 249 yards receiving (15.6 per game) on 39 receptions (2.4 per game) while being targeted 49 times. He had three TD catches.
• Xavier Legette was targeted 84 times, resulting in 49 receptions for 497 yards.

Defense

• Christian Rozeboom's 2024 season included 133 tackles, five TFL, one sack, and one interception in 16 games for the Rams.
• Tre'von Moehrig posted 104 tackles, five TFL, one sack, and two interceptions for the Raiders.
• A'Shawn Robinson had 80 tackles, eight TFL, 5.5 sacks, and one pass defended in 2024.
• Mike Jackson Sr. had three TFL, 76 tackles, and two interceptions.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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