Eagles vs. Chiefs 2025 Prediction, Odds, Picks - Sep 14

Updated Sep. 14, 2025 12:43 p.m. ET

Data Skrive

The Philadelphia Eagles (1-0) are favored by 1.5 points versus the Kansas City Chiefs (0-1) on September 14, 2025, starting at 4:25 p.m. ET, airing on FOX. The matchup has an over/under of 47.5 points.

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Eagles vs. Chiefs Odds & Betting Lines

Eagles vs Chiefs Betting Information updated as of September 13, 2025, 9:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Eagles	-1.5	-108	-112	47.5	-106	-125

Eagles vs. Chiefs Prediction & Pick

Pick ATS: Chiefs (+1.5)
Pick OU: Under (47.5)
Prediction: Eagles 22 - Chiefs 21

How to Watch Philadelphia vs. Kansas City

Game date: Sunday, September 14, 2025
Time: 4:25 p.m. ET
Venue: GEHA Field at Arrowhead Stadium
Location: Kansas City, Missouri
TV: Watch on FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Eagles vs. Chiefs Recent Matchups

Kansas City has a 3-2 record against Philadelphia in their last five matchups.
Philadelphia and Kansas City have matched up evenly on offense over their last five matchups, with each team putting up 146 points in those games.

Philadelphia Betting Info

Philadelphia won 11 games against the spread last season, failing to cover six times.
The Eagles went 8-5 ATS as 1.5-point favorites or greater last year.
Philadelphia games hit the over seven out of 17 times last season.
The Eagles were the moneyline favorite 14 total times last season. They finished 11-3 in those games.
Philadelphia went 11-2 when it played as a moneyline favorite with odds of -122 or shorter (84.6%).
Based on this game's moneyline, the Eagles' implied win probability is 55.0%.

Eagles Stats (2024)

Stat	Average (Total)	Rank
Pass yards	187.9 (3,194)	29
Rush yards	179.3 (3,048)	2
Points scored	27.2 (463)	7
Pass yards against	174.2 (2,961)	1
Rush yards against	104.2 (1,771)	10
Points allowed	17.8 (303)	2

Philadelphia's Key Players

Offense

Saquon Barkley rushed for 13 touchdowns last year, and racked up 2,005 total rushing yards (125.3 per game and 5.8 per attempt).
On top of his impact in the run game, Barkley caught 33 passes (on 43 targets) for 278 yards, with two receiving touchdowns. He averaged 17.4 yards per game.
Over the course of 15 games, Jalen Hurts had 2,903 passing yards, with 18 touchdowns against five interceptions and completing 68.7% of his attempts.
Hurts also had 14 rushing touchdowns and 630 rushing yards.
Last year, A.J. Brown caught 67 passes for 1,079 receiving yards with seven touchdowns through the air. He was targeted 97 total times and averaged 5.2 receptions per game over 13 games played.
DeVonta Smith was targeted 89 times, resulting in 68 catches for 833 yards.

Defense

Zack Baun intercepted one pass in addition to 150 tackles, 11.0 TFL, 3.5 sacks, and four passes defended in 2024.
Reed Blankenship's stats included four interceptions (10th in the NFL) as well as 78 tackles and six passes defended.
Over the 2024 season, Jalen Carter had 42 tackles, 12.0 TFL, and 4.5 sacks over 16 games.
Za'Darius Smith's stat sheet included 35 tackles, 9.0 TFL, nine sacks, and one pass defended in 16 games

Kansas City Betting Info

Kansas City put together a 7-10-0 ATS record last season.
As a 1.5-point underdog or more, the Chiefs had one win ATS (1-2) last season.
Last season, seven Kansas City games went over the point total.
The Chiefs won one of the three games they played as underdogs last season.
Last season, Kansas City won one of its three games when it was the underdog by at least +102 on the moneyline.
The bookmakers' moneyline implies a 49.5% chance of a victory for the Chiefs.

Chiefs Stats (2024)

Stat	Average (Total)	Rank
Pass yards	222.4 (3,780)	14
Rush yards	105.3 (1,790)	22
Points scored	22.6 (385)	15
Pass yards against	218.8 (3,720)	18
Rush yards against	101.8 (1,731)	8
Points allowed	19.2 (326)	4

Kansas City's Key Players

Offense

Patrick Mahomes averaged 6.8 passing yards per attempt (26th in NFL) and 245.5 yards per game last season, completing 67.5% of his passes on the way to 3,928 total yards (seventh in NFL), 26 TDs (ninth in NFL) and 11 INTs in 16 games.
On the ground, Mahomes added two TDs and 307 yards.
Kareem Hunt scored seven rushing TDs, totaling 728 yards (3.6 per attempt and 56.0 per game).
Hunt also had 23 catches for 176 yards. He was targeted 32 times and averaged 13.5 yards per game.
Last year, Xavier Worthy caught 59 passes for 638 yards and six TDs . He was targeted 98 times, and averaged 3.7 receptions in 16 games.
Travis Kelce had 823 yards receiving and three TDs via 97 catches on 133 targets.

Defense

In 2024, Nick Bolton put up 106 tackles, 11.0 TFL, three sacks, and one interception in 16 games.
Drue Tranquill had 2.0 sacks plus 4.0 TFL and 94 tackles.
Over the 2024 campaign, Chamarri Conner posted 70 tackles, 4.0 TFL, one sack, and two interceptions in 15 games.
George Karlaftis III had 8.0 sacks plus 9.0 TFL and 35 tackles in 16 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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