Cardinals vs. Panthers 2025 Prediction, Odds, Picks - Sep 14

The Arizona Cardinals (1-0) are favored by seven points versus the Carolina Panthers (0-1) on September 14, 2025, starting at 4:05 p.m. ET, airing on CBS. The predicted point total for the game is 45.5.

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Cardinals vs. Panthers Odds & Betting Lines

Cardinals vs. Panthers Prediction & Pick

• Pick ATS: Cardinals (-7)
  
• Pick OU: Over (45.5)
  
• Prediction: Cardinals 34 - Panthers 15

How to Watch Arizona vs. Carolina

• Game date: Sunday, September 14, 2025
• Time: 4:05 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: CBS
• Live Boxscore: FOX Sports

Cardinals vs. Panthers Recent Matchups

• Carolina holds a 3-1 record against Arizona in their last four matchups.
• Arizona has been outpaced by 38 points in its last four tilts against Carolina.

Arizona Betting Info

• Arizona compiled an 11-6-0 ATS record last year.
• Arizona and its opponent combined to hit the over in eight of 17 contests last season.
• The Cardinals won 42.9% of the games last season when they were favored on the moneyline (3-4).
• Arizona did not play a game last season with moneyline odds of -305 or shorter.
• Based on this game's moneyline, the Cardinals have an implied win probability of 75.3%.

Cardinals Stats (2024)

Arizona's Key Players

Offense

• Over the course of 17 games played last year, Kyler Murray totaled 3,851 passing yards, with 21 touchdowns against 11 interceptions and completing 68.8% of his passes.
• On the ground, Murray added five rushing touchdowns and 572 rushing yards.
• James Conner scored eight rushing touchdowns, while totaling 1,094 rushing yards (4.6 per attempt and 68.4 per game).
• Conner also collected 414 receiving yards (25.9 per game) on 47 catches (2.9 per game). He was targeted 55 times and caught one touchdown pass.
• Marvin Harrison Jr. totaled 885 receiving yards and eight touchdowns on 62 receptions while being targeted 116 times last year.
• Trey McBride was targeted 147 times, resulting in 111 catches (fourth in the NFL) for 1,146 yards.

Defense

• Budda Baker amassed 2.0 sacks to go with 10.0 TFL and 164 tackles over 17 games in 2024.
• Jalen Thompson had 98 tackles, 3.0 TFL, and three passes defended.
• Calais Campbell had 5.0 sacks in addition to his 12.0 TFL and 52 tackles for the Dolphins.
• Mack Wilson registered 3.0 sacks to go with 4.0 TFL, 75 tackles, and one interception over 15 games.

Carolina Betting Info

• Carolina compiled an 8-9-0 record against the spread last year.
• The Panthers' ATS record as underdogs of 7 points or more was 5-3 last year.
• Last year, 13 Carolina games went over the point total.
• The Panthers were underdogs 16 times last season and won five, or 31.2%, of those games.
• Carolina entered seven games last season as the underdog by +245 or more and were 2-5 in those contests.
• The sportsbooks' moneyline implies a 29.0% chance of a victory for the Panthers.

Panthers Stats (2024)

Carolina's Key Players

Offense

• Chuba Hubbard averaged 79.7 yards rushing last season (1,195 total yards to rank eighth in the NFL,) while scoring 10 rushing TDs.
• Hubbard also was a part of the pass attack with 171 receiving yards (11.4 per game) on 43 receptions (2.9 per game), targeted 54 times. He had one receiving TD.
• Bryce Young had 2,403 passing yards, 15 TD passes and nine INTs. His completion percentage was 60.9% and he averaged 171.6 yards per game and 6.3 per attempt.
• He added 249 yards rushing, with six TDs on the ground (averaging 17.8 yards per game and 5.8 per carry).
• Rico Dowdle averaged 67.4 yards rushing per game for the Cowboys last season (1,079 total yards), while scoring two rushing TDs.
• Dowdle helped out in the pass attack, putting up 249 yards receiving (15.6 per game) on 39 receptions (2.4 per game) while being targeted 49 times. He had three TD catches.
• Xavier Legette had 49 receptions for 497 yards and four TDs. He averaged 3.3 yards per game in 15 games and was targeted 84 times.

Defense

• Christian Rozeboom put up 1.0 sack to go with 5.0 TFL, 133 tackles, and one interception in 16 games for the Rams during the 2024 season.
• With the Raiders last season, Tre'von Moehrig had 1.0 sack plus 5.0 TFL, 104 tackles, and two interceptions.
• A'Shawn Robinson posted 5.5 sacks in addition to his 8.0 TFL and 80 tackles.
• Mike Jackson Sr.'s stats for the year included 76 tackles, 3.0 TFL, and two interceptions in 17 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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