Bills vs. Falcons 2025 Prediction, Odds, Picks - Oct 13

The Buffalo Bills (4-1) are favored by 4.5 points versus the Atlanta Falcons (2-2) on October 13, 2025, starting at 7:15 p.m. ET, airing on ESPN. The matchup has an over/under of 50.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Bills vs. Falcons Odds & Betting Lines

Bills vs. Falcons Prediction & Pick

• Pick ATS: Falcons (+4.5)
  
• Pick OU: Under (50.5)
  
• Prediction: Falcons 25 - Bills 22

How to Watch Buffalo vs. Atlanta

• Game date: Monday, October 13, 2025
• Time: 7:15 p.m. ET
• Venue: Mercedes-Benz Stadium
• Location: Atlanta, Georgia
• TV: ESPN
• Live Boxscore: FOX Sports

Bills vs. Falcons Recent Matchups

• Buffalo holds a 2-0 record against Atlanta in their last two matchups.
• In their last two head-to-head matchups, Buffalo has scored 52 points versus Atlanta, while allowing only 32 points.

Buffalo Betting Info

• So far this season Buffalo has two victories against the spread.
• The Bills have covered the spread once when favored by 4.5 points or more this season (in four opportunities).
• Buffalo games this year have gone over the total in three out of five opportunities (60%).
• The Bills have won 75% of the time they have played as the moneyline favorite (3-1).
• Based on this game's moneyline, the Bills' implied win probability is 68.6%.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 1,217 passing yards in five games this year, averaging 243.4 per game with a 70.4% completion percentage and nine touchdowns against two interceptions.
• He has added 212 rushing yards (42.4 per game) and three touchdowns on the ground.
• James Cook averages 5 yards per carry (11th in the NFL) and 90 yards per game, and has 450 total rushing yards (fifth in the NFL). He has scored five rushing TDs this season.
• He has also hauled in 12 passes (on 14 targets) for 89 receiving yards with zero touchdowns. He's averaging 17.8 receiving yards and 2.4 catches per game.
• Dalton Kincaid has three touchdown catches this season, and has 20 catches for 287 yards on 24 targets, while averaging four catches and 57.4 yards per game.
• Khalil Shakir has 235 receiving yards and two touchdowns with 22 catches on 29 targets. He is averaging 4.4 receptions and 47 yards per game.

Defense

• Over on defense, Terrel Bernard has 26 tackles, three TFL, and one interception in 2025. His tackle total leads the Bills.
• Cole Bishop has 21 tackles, one TFL, two sacks, and one interception this season.
• Joey Bosa has totaled nine tackles, two TFL, and two sacks this year.
• Tre'Davious White has four TFL and 19 tackles on the season.

Atlanta Betting Info

• Atlanta has registered a win-loss record of 2-2-0 against the spread this year.
• Games involving Atlanta have hit the over once this year.
• The Falcons have split the two games they've played as underdogs this season.
• The oddsmakers' moneyline implies a 35.7% chance of a victory for the Falcons.

Falcons Stats

Atlanta's Key Players

Offense

• This year in four games, Bijan Robinson has racked up 314 rushing yards (leading the Falcons) and scored one rushing touchdown. He averages 78.5 yards per game and 4.9 per attempt (13th in the NFL).
• Robinson's contributions include 18 receptions (4.5 per game) on 23 targets for 270 yards (67.5 per game) and one receiving touchdown.
• In four games, Michael Penix Jr. has 918 passing yards, while throwing three touchdowns against three interceptions and completing 62.4% of his passes.
• Penix also has one rushing touchdown and 31 rushing yards (fourth on the Falcons).
• So far this season, Drake London has caught 24 passes for 269 receiving yards with one touchdown through the air. He has been targeted 37 total times and is averaging six receptions per game in four games played.
• Tyler Allgeier puts up 38.8 rushing yards per game through four games (155 total yards), with two rushing touchdowns.

Defense

• Kaden Elliss has 23 tackles, four TFL, 1.5 sacks, and one pass defended in 2025.
• Xavier Watts' stats include two interceptions (fifth in the NFL) as well as 22 tackles and four passes defended.
• Billy Bowman has intercepted one pass on top of 17 tackles, 0.5 sacks, and two passes defended during the 2025 season.
• Zach Harrison has 2.5 sacks (first on the Falcons) to go with two TFL and 11 tackles through four games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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