49ers vs. Panthers 2025 Prediction, Odds, Picks - Nov 24

The San Francisco 49ers (7-4) are considered favorites (-7.5) according to the point spread ahead of their game versus the Carolina Panthers (6-5) on November 24, 2025, starting at 8:15 p.m. ET, airing on ESPN. The matchup has an over/under of 49.5 points.

Keep up with the 2025 NFL season on FOX Sports.

49ers vs. Panthers Odds & Betting Lines

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

49ers vs. Panthers Prediction & Pick

• Pick ATS: 49ers (-7.5)
  
• Pick OU: Under (49.5)
  
• Prediction: 49ers 29 - Panthers 15

How to Watch San Francisco vs. Carolina

• Game date: Monday, November 24, 2025
• Time: 8:15 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: ESPN
• Live Boxscore: FOX Sports

49ers vs. Panthers Recent Matchups

• Over their last three meetings, San Francisco has collected two wins against Carolina.
• Over their last three head-to-head contests, San Francisco has put up 91 points, while Carolina has accumulated 51.

San Francisco Betting Info

• San Francisco has six wins in 11 games versus the spread this year.
• San Francisco games this year have hit the over on seven of 11 set point totals (63.6%).
• When playing as moneyline favorites, the 49ers are 6-1, winning 85.7% of the time.
• The 49ers have a 79.8% chance to win this matchup, based on the implied probability of the moneyline.

49ers Stats

San Francisco's Key Players

Offense

• Christian McCaffrey's rushing stat line this season includes 707 yards and six TDs. He is averaging 64.3 yards per game and 3.7 per attempt (37th in the NFL).
• He has hauled in 74 passes (on 96 targets) for 732 receiving yards with five touchdowns. He's averaging 66.5 receving yards and 6.7 catches per game.
• Mac Jones has thrown for 2,151 yards, 13 touchdowns and six interceptions this year. He is averaging 239 yards per game and 7.4 per attempt, while completing 69.6%.
• Jauan Jennings has three touchdown catches this season, and has 32 catches for 378 yards on 56 targets, while averaging 3.6 catches and 42 yards per game.
• George Kittle has 27 catches for 251 yards and five touchdowns. He's been targeted 30 times in the passing game, and averages 4.5 receptions and 41.8 yards in six games played.

Defense

• On the defensive side, Dee Winters has six TFL and 77 tackles in 2025.
• Upton Stout has 51 tackles, three TFL, and one sack this season.
• Bryce Huff has totaled 20 tackles, six TFL, and four sacks this year.
• Tatum Bethune has 64 tackles, two TFL, and one pass defended.

Carolina Betting Info

• Carolina is 7-4-0 against the spread this season.
• The Panthers have been underdogs by 7.5 points or more two times this year and covered the spread once.
• Carolina's games have finished with a final combined score above the over/under six times this year.
• The Panthers have been underdogs in 10 games this season and won six (60%) of those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Panthers have a 24.4% chance to win.

Panthers Stats

Carolina's Key Players

Offense

• This year through 11 games, Rico Dowdle has churned out 833 rushing yards (leading the Panthers and eighth in the NFL) and scored five rushing touchdowns. He averages 75.7 yards per game and 5 per carry (seventh in the NFL).
• On top of his impact on the ground, Dowdle has caught 23 passes (on 30 targets) for 197 yards (third on the Panthers), with one receiving touchdown. He's averaging 17.9 yards per game.
• Through 10 games, Bryce Young has 1,962 passing yards, while throwing 14 touchdowns against seven interceptions and completing 62.7% of his attempts.
• Young also has one rushing touchdown and 83 rushing yards (fourth on the Panthers).
• So far this season, Tetairoa McMillan has caught 54 passes for 748 receiving yards with four touchdowns through the air. He has been targeted 89 total times and is averaging 4.9 receptions per game through 11 games played.
• Chuba Hubbard puts up 37.1 rushing yards per game over nine games (334 total yards), with one rushing touchdown.
• Hubbard has added 17 catches (1.9 per game) for 126 yards (14 per game) and two receiving touchdowns. He has been on the receiving end of 26 targets.

Defense

• In 2025, Tre'von Moehrig has put up one sack to go with nine TFL, 73 tackles, and one interception through 11 games.
• Christian Rozeboom has registered five TFL and 91 tackles through 11 games.
• During the 2025 season, Trevin Wallace has 52 tackles, four TFL, and two sacks in 10 games.
• Derrick Brown has totaled three sacks (first on the Panthers) as well as three TFL and 40 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco 49ers

Carolina Panthers