2025 NFL Week 16 Predictions, Betting Odds & TV Schedule

The Week 16 NFL slate includes top teams in play. Among those games is the Los Angeles Rams squaring off against the Seattle Seahawks.

Here's everything you need to know in terms of the betting odds for Week 16 in the NFL.

Check out the full NFL schedule on FOX Sports!

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Week 16 Betting Lines & Game Info

Seattle Seahawks vs. Los Angeles Rams

Odds & Prediction

• Spread: Seahawks (-1.5)
• Moneyline: Seahawks -123, Rams +103
• Total: 42.5 points
• Prediction: Seahawks 25, Rams 24

How to Watch

• Game Date: Thursday, Dec. 18
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: Seattle, Washington

Washington Commanders vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-7)
• Moneyline: Eagles -373, Commanders +292
• Total: 43.5 points
• Prediction: Eagles 28, Commanders 17

How to Watch

• Game Date: Saturday, Dec. 20
• Game Time: 5 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Landover, Maryland

Chicago Bears vs. Green Bay Packers

Odds & Prediction

• Spread: Bears (-1.5)
• Moneyline: Bears -119, Packers -100
• Total: 45 points
• Prediction: Bears 25, Packers 23

How to Watch

• Game Date: Saturday, Dec. 20
• Game Time: 8:20 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Chicago, Illinois

Tennessee Titans vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-3.5)
• Moneyline: Chiefs -176, Titans +147
• Total: 37.5 points
• Prediction: Chiefs 25, Titans 18

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Nashville, Tennessee

Dallas Cowboys vs. Los Angeles Chargers

Odds & Prediction

• Spread: Cowboys (-1.5)
• Moneyline: Cowboys -121, Chargers +101
• Total: 50.5 points
• Prediction: Chargers 26, Cowboys 25

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Arlington, Texas

Miami Dolphins vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-3.5)
• Moneyline: Bengals -204, Dolphins +169
• Total: 48.5 points
• Prediction: Dolphins 28, Bengals 21

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Miami Gardens, Florida

New York Giants vs. Minnesota Vikings

Odds & Prediction

• Spread: Vikings (-2.5)
• Moneyline: Vikings -147, Giants +123
• Total: 41.5 points
• Prediction: Vikings 24, Giants 23

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: East Rutherford, New Jersey

New Orleans Saints vs. New York Jets

Odds & Prediction

• Spread: Saints (-6.5)
• Moneyline: Saints -299, Jets +241
• Total: 39.5 points
• Prediction: Saints 27, Jets 17

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: New Orleans, Louisiana

Carolina Panthers vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Buccaneers (-3)
• Moneyline: Buccaneers -156, Panthers +131
• Total: 44.5 points
• Prediction: Buccaneers 23, Panthers 22

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Charlotte, North Carolina

Cleveland Browns vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-10.5)
• Moneyline: Bills -595, Browns +436
• Total: 41.5 points
• Prediction: Bills 31, Browns 15

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Cleveland, Ohio

Arizona Cardinals vs. Atlanta Falcons

Odds & Prediction

• Spread: Falcons (-2.5)
• Moneyline: Falcons -153, Cardinals +128
• Total: 48.5 points
• Prediction: Cardinals 25, Falcons 22

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Glendale, Arizona

Denver Broncos vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Broncos (-3.5)
• Moneyline: Broncos -182, Jaguars +152
• Total: 46.5 points
• Prediction: Jaguars 23, Broncos 22

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Denver, Colorado

Houston Texans vs. Las Vegas Raiders

Odds & Prediction

• Spread: Texans (-14)
• Moneyline: Texans -1316, Raiders +782
• Total: 39.5 points
• Prediction: Texans 34, Raiders 6

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Houston, Texas

Detroit Lions vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Lions (-7.5)
• Moneyline: Lions -395, Steelers +313
• Total: 52 points
• Prediction: Lions 29, Steelers 22

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Detroit, Michigan

Baltimore Ravens vs. New England Patriots

Odds & Prediction

• Spread: Ravens (-3.5)
• Moneyline: Ravens -196, Patriots +161
• Total: 48.5 points
• Prediction: Patriots 24, Ravens 22

How to Watch

• Game Date: Sunday, Dec. 21
• Game Time: 8:20 p.m. ET
• TV Channel: NBC/Peacock
• Box Score
• Location: Baltimore, Maryland

Indianapolis Colts vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-4.5)
• Moneyline: 49ers -223, Colts +185
• Total: 46.5 points
• Prediction: Colts 24, 49ers 23

How to Watch

• Game Date: Monday, Dec. 22
• Game Time: 8:15 p.m. ET
• TV Channel: ESPN
• Box Score
• Location: Indianapolis, Indiana

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

National Football League