2025 NFL Week 16 Predictions, Betting Odds & TV Schedule

2025 NFL Week 16 Predictions, Betting Odds & TV Schedule

Published Dec. 17, 2025 12:07 a.m. ET
Data Skrive

The Los Angeles Rams and the Seattle Seahawks square off in one of many exciting matchups on the NFL slate in Week 16.

Here's what you need to know in terms of the betting odds for Week 16 in the NFL.

Check out the full NFL schedule on FOX Sports!

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Week 16 Betting Lines & Game Info

Seattle Seahawks vs. Los Angeles Rams

Odds & Prediction

  • Spread: Rams (-1.5)
  • Moneyline: Rams -110, Seahawks -109
  • Total: 44 points
  • Prediction: Seahawks 25, Rams 24

How to Watch

  • Game Date: Thursday, Dec. 18
  • Game Time: 8:15 p.m. ET
  • TV Channel: Amazon Prime Video
  • Box Score
  • Location: Seattle, Washington

Washington Commanders vs. Philadelphia Eagles

Odds & Prediction

  • Spread: Eagles (-6.5)
  • Moneyline: Eagles -299, Commanders +240
  • Total: 44.5 points
  • Prediction: Eagles 27, Commanders 17

How to Watch

Chicago Bears vs. Green Bay Packers

Odds & Prediction

  • Spread: Packers (-1.5)
  • Moneyline: Packers -115, Bears -103
  • Total: 46.5 points
  • Prediction: Bears 25, Packers 23

How to Watch

Miami Dolphins vs. Cincinnati Bengals

Odds & Prediction

  • Spread: Bengals (-2.5)
  • Moneyline: Bengals -138, Dolphins +117
  • Total: 50.5 points
  • Prediction: Dolphins 28, Bengals 21

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 1 p.m. ET
  • TV Channel: NBC
  • Box Score
  • Location: Miami Gardens, Florida

New York Giants vs. Minnesota Vikings

Odds & Prediction

  • Spread: Vikings (-3)
  • Moneyline: Vikings -153, Giants +129
  • Total: 43.5 points
  • Prediction: Vikings 24, Giants 23

How to Watch

New Orleans Saints vs. New York Jets

Odds & Prediction

  • Spread: Saints (-4.5)
  • Moneyline: Saints -218, Jets +181
  • Total: 40.5 points
  • Prediction: Saints 27, Jets 17

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: New Orleans, Louisiana

Carolina Panthers vs. Tampa Bay Buccaneers

Odds & Prediction

  • Spread: Buccaneers (-3)
  • Moneyline: Buccaneers -159, Panthers +133
  • Total: 45.5 points
  • Prediction: Buccaneers 23, Panthers 22

How to Watch

Tennessee Titans vs. Kansas City Chiefs

Odds & Prediction

  • Spread: Chiefs (-3.5)
  • Moneyline: Chiefs -188, Titans +156
  • Total: 37.5 points
  • Prediction: Chiefs 25, Titans 18

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Nashville, Tennessee

Cleveland Browns vs. Buffalo Bills

Odds & Prediction

  • Spread: Bills (-10)
  • Moneyline: Bills -592, Browns +431
  • Total: 42 points
  • Prediction: Bills 31, Browns 15

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Cleveland, Ohio

Dallas Cowboys vs. Los Angeles Chargers

Odds & Prediction

  • Spread: Cowboys (-2.5)
  • Moneyline: Cowboys -130, Chargers +109
  • Total: 49.5 points
  • Prediction: Chargers 26, Cowboys 25

How to Watch

Denver Broncos vs. Jacksonville Jaguars

Odds & Prediction

  • Spread: Broncos (-3)
  • Moneyline: Broncos -167, Jaguars +141
  • Total: 45.5 points
  • Prediction: Jaguars 23, Broncos 22

How to Watch

Arizona Cardinals vs. Atlanta Falcons

Odds & Prediction

  • Spread: Falcons (-2.5)
  • Moneyline: Falcons -147, Cardinals +124
  • Total: 47.5 points
  • Prediction: Cardinals 24, Falcons 23

How to Watch

Detroit Lions vs. Pittsburgh Steelers

Odds & Prediction

  • Spread: Lions (-7)
  • Moneyline: Lions -333, Steelers +268
  • Total: 52 points
  • Prediction: Lions 29, Steelers 22

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 4:25 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Detroit, Michigan

Houston Texans vs. Las Vegas Raiders

Odds & Prediction

  • Spread: Texans (-14.5)
  • Moneyline: Texans -1316, Raiders +800
  • Total: 38.5 points
  • Prediction: Texans 34, Raiders 6

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 4:25 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Houston, Texas

Baltimore Ravens vs. New England Patriots

Odds & Prediction

  • Spread: Ravens (-3)
  • Moneyline: Ravens -154, Patriots +129
  • Total: 48 points
  • Prediction: Patriots 24, Ravens 23

How to Watch

  • Game Date: Sunday, Dec. 21
  • Game Time: 8:20 p.m. ET
  • TV Channel: NBC/Peacock
  • Box Score
  • Location: Baltimore, Maryland

Indianapolis Colts vs. San Francisco 49ers

Odds & Prediction

  • Spread: 49ers (-6.5)
  • Moneyline: 49ers -285, Colts +232
  • Total: 46.5 points
  • Prediction: Colts 24, 49ers 23

How to Watch

  • Game Date: Monday, Dec. 22
  • Game Time: 8:15 p.m. ET
  • TV Channel: ESPN
  • Box Score
  • Location: Indianapolis, Indiana

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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