Cavaliers vs. 76ers Prediction, Odds, Picks - Nov. 5

The Cleveland Cavaliers (4-3) face the Philadelphia 76ers (5-2) on November 5, 2025. The matchup airs on FDSOH and NBCS-PH. Wednesday's matchup between the Cavaliers and the 76ers features the Cavaliers as sizable 10.5-point favorites. The game has an over/under of 235.5.

Here's everything you need to know to know about the Cavaliers-76ers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Cavaliers vs. 76ers Game Information, TV Channel & Odds

• When: Wednesday, November 5, 2025 at 7 p.m. ET
• Where: Rocket Arena in Cleveland, Ohio
• TV: FDSOH and NBCS-PH
• Live Boxscore: FOX Sports

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Cavaliers vs. 76ers Prediction

ATS Pick: 76ers (+ 10.5)
O/U Pick: Under (235.5)
Score Prediction: Cavaliers 118 - 76ers 117

Cavaliers vs. 76ers Betting Insights

• The Cavaliers have played one game with more than 235.5 points scored, their current matchup's over/under, this year.
• This year, three of the 76ers' seven games have had a combined total of more than 235.5 points scored.
• These teams average 237.7 points per game combined, 2.2 more than the total of 235.5.
• Opponents of the two teams average a combined 4.2 fewer points per game (231.3) than this matchup's over/under of 235.5 points.
• Cleveland has been the favorite in seven games this season and has come away with the win four times (57.1%) in those contests.
• Philadelphia has been chosen as underdogs in four games this year and has walked away with the win two times (50%) in those games.
• In the last three head-to-head meetings, Cleveland has a 2-1 record against Philadelphia.
• The 76ers have a 2-1 advantage against the spread when matched up with the Cavaliers.

Cavaliers Recent Trends

• The Cavaliers have two wins against the spread in seven games this year.
• Cleveland has been favored by 10.5 points or more one time this season and have not covered the spread in any of them.
• Cavaliers games this year have hit the over on two of seven set point totals.
• The Cavaliers average 114.1 points per game, just 3.3 fewer points than the 117.4 the 76ers give up.
• Cleveland has a 0-2 record against the spread and a 2-0 record overall when putting up more than 117.4 points.
• The Cavaliers are shooting 44.5% from the field this season, 2.5 percentage points lower than the 47% the 76ers allow to opponents.

Cavaliers Recent Stats

Cavaliers Leaders

• Evan Mobley posts 19.3 points, 4.4 assists and 8.9 rebounds per game.
• Donovan Mitchell averages 29.5 points, 2.3 rebounds and 4.5 assists per game, shooting 55% from the floor and 43.6% from beyond the arc with 4 made treys per contest (third in NBA).
• De'Andre Hunter averages 18.4 points, 5.6 rebounds and 3 assists per contest. At the other end, he averages 0.8 steals and 0.2 blocks.
• Jarrett Allen averages 14 points, 1.8 assists and 7 boards.
• Jaylon Tyson posts 10.9 points, 2.7 boards and 1.6 assists per game, shooting 50% from the field and 44.1% from beyond the arc with 2.1 made 3-pointers per game.

Cavaliers Player Props

76ers Recent Trends

• The 76ers are 4-2-1 against the spread this year.
• 76ers games this season have gone over the total in five of seven opportunities (71.4%).
• The 76ers score an average of 123.6 points per game, 9.7 more points than the 113.9 the Cavaliers allow to opponents.
• Philadelphia has put together a 4-1 ATS record and a 5-0 overall record in games it scores more than 113.9 points.
• The 76ers are shooting 47.1% from the field, 0.6% higher than the 46.5% the Cavaliers' opponents have shot this season.

76ers Recent Stats

76ers Leaders

• Tyrese Maxey puts up 34.4 points, 4.9 rebounds and 8.4 assists per game for the 76ers.
• The 76ers are receiving 19.1 points, 5.9 rebounds and 4.9 assists per game from VJ Edgecombe this season.
• The 76ers are receiving 19.3 points, 5.9 rebounds and 1.3 assists per game from Kelly Oubre Jr. this year.
• The 76ers are receiving 17 points, 4.4 rebounds and 5 assists per game from Quentin Grimes this year.
• Joel Embiid gets the 76ers 17.8 points, 5.4 rebounds and 3.2 assists per game while posting 1 steal and 1.6 blocked shots (ninth in NBA).

76ers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.