Red Sox vs. Athletics Prediction, Odds, Picks - September 18

Trevor Story and Brent Rooker will be among the star attractions when the Boston Red Sox face the Athletics on Thursday at 1:35 p.m. ET, at Fenway Park. The Red Sox are listed as -149 moneyline favorites in this matchup with the Athletics (+125). The Red Sox are favored on the run line (-1.5). The matchup's over/under is set at 9 runs.

Here is everything you need to know from a betting perspective on the Red Sox-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Athletics vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Athletics and the Boston Red Sox.

Red Sox vs. Athletics Game Information & Odds

• When: Thursday, September 18, 2025 at 1:35 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and NBCS-CA

Red Sox vs. Athletics Prediction

• Score Prediction: Red Sox 5, Athletics 4
• Total Prediction: Under 9 runs
• Win Probabilities: Red Sox 56%, Athletics 44%

Red Sox vs. Athletics Betting Insights

• The Red Sox have been favorites in 94 games this season and won 55 (58.5%) of those contests.
• This season, the Red Sox have won 22 of their 37 games, or 59.5%, when favored by at least -149 on the moneyline.
• The Red Sox have a 59.8% chance to win this game based on the implied probability of the moneyline.
• The Athletics have been chosen as underdogs in 115 games this year and have walked away with the win 54 times (47%) in those games.
• This season, the Athletics have come away with a win 19 times in 56 chances when named as an underdog of at least +125 or longer on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Athletics have a 44.4% chance of pulling out a win.

Red Sox Recent Betting Performance

• The Red Sox went 3-3 across the six games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Red Sox and their opponents combined to go over the total two times.
• The Red Sox's record against the spread is 4-6-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran gets on base at a .337 clip while slugging .451, both marks that lead the Red Sox. He also has the team high in hits with 152.
• Of all hitters in the majors, Duran's home run total ranks him 132nd, and his RBI tally puts him 40th.
• Duran takes a hitting streak of four games into this game. During his last five outings he is batting .375 with a triple, a home run, two walks and an RBI.
• Story has hit 24 home runs with 92 RBI while hitting .266. Those stats all pace his team.
• Story ranks 47th in homers and 19th in RBI among all major league hitters this season.
• Story carries a three-game streak with at least one hit into this matchup. In his last five games he is hitting .350 with a walk and an RBI.
• Alex Bregman has 27 doubles, 17 home runs and 44 walks while hitting .272.
• Ceddanne Rafaela is hitting .239 with 29 doubles, three triples, 16 home runs and 25 walks.
• Rafaela has recorded at least one hit in two games in a row. In his last five games he is hitting .176 with two walks.

Red Sox Team Props

Athletics Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Athletics have a record of 5-2.
• In their last 10 games with a total, the Athletics and their opponents have failed to hit the over seven times.
• The Athletics have a record of 7-3-0 ATS over their last 10 games.

Athletics Recent Stats

Athletics Player Insights

• Rooker is batting .267 with 40 doubles, three triples, 29 home runs and 61 walks, while getting on base at a rate of .339.
• In all of MLB, Rooker is 21st in home runs and 29th in RBI.
• Tyler Soderstrom has capitalized on opportunities as he paces his team with 89 runs batted in.
• Soderstrom ranks 47th among all batters in the big leagues in home runs, and 25th in RBI.
• Jacob Wilson has accumulated a team-best batting average of .321.
• Nick Kurtz has swatted a team-leading 32 home runs.

Athletics Team Props

Athletics vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Athletics and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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