Rays vs. Guardians Prediction, Odds, Picks - September 7

Jose Ramirez and the Cleveland Guardians match up with Josh Lowe and the Tampa Bay Rays on Sunday at 12:10 p.m. ET at George M. Steinbrenner Field. The Rays are -160 moneyline favorites in this matchup against the Guardians (+134). Tampa Bay (-1.5) is the favorite on the run line. The total is 8 runs for the game.

Take a look at everything you need to know from a betting perspective on the Rays-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and the Tampa Bay Rays.

Rays vs. Guardians Game Information & Odds

• When: Sunday, September 7, 2025 at 12:10 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and CLEG

Rays vs. Guardians Prediction

• Score Prediction: Rays 4, Guardians 3
• Total Prediction: Under 8 runs
• Win Probabilities: Rays 56%, Guardians 44%

Rays vs. Guardians Betting Insights

• The Rays have been favorites in 71 games this season and won 42 (59.2%) of those contests.
• This season Tampa Bay has won eight of its 18 games, or 44.4%, when favored by at least -160 on the moneyline.
• The implied probability of a win from the Rays, based on the moneyline, is 61.5%.
• The Guardians have come away with 36 wins in the 81 contests they have been listed as the underdogs in this season.
• This year, Cleveland has won nine of 25 games when listed as at least +134 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 42.7% chance of walking away with the win.

Rays Recent Betting Performance

• The Rays have a 5-3 record from the eight games they were favored on the moneyline over their last 10 matchups.
• In their last 10 matchups, the Rays and their opponents combined to go over the run total five times (all 10 games had set totals).
• The Rays have a 7-3-0 record against the spread over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Junior Caminero leads the Rays with 41 home runs and 103 runs batted in.
• Of all hitters in baseball, Caminero's home run total ranks him sixth, and his RBI tally ranks him fifth.
• Yandy Diaz has a club-best .293 batting average.
• Diaz is 49th in home runs and 38th in RBI in the bigs.
• Diaz heads into this game looking for his third game in a row with a hit. During his last five outings he is batting .474 with a double, two walks and an RBI.
• Brandon Lowe is hitting .262 with 16 doubles, 28 home runs and 35 walks.
• Chandler Simpson has 11 doubles, three triples and 18 walks while hitting .288.

Rays Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in 10 of their past 10 games and won six of those contests.
• In their last 10 games with a total, the Guardians and their opponents are 4-4-2 when it comes to hitting the over.
• The Guardians have a record of 6-4-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the Guardians in home runs (27), runs batted in (73) and has posted a team-best batting average of .283.
• Among all hitters in the big leagues, Ramirez's home run total is 25th and his RBI tally is 49th.
• Ramirez carries a three-game hitting streak into this matchup. In his last five games he is batting .368 with two doubles, a home run, a walk and five RBIs.
• Steven Kwan has 25 doubles, a triple, 10 home runs and 47 walks while batting .275.
• Kwan ranks 184th overall in homers and 161st in RBI this season.
• Kyle Manzardo is hitting .233 with 14 doubles, two triples, 25 home runs and 44 walks.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while hitting .224.

Guardians Team Props

Guardians vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and the Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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