Rays vs. Cardinals Prediction, Odds, Picks - August 22

The Tampa Bay Rays and St. Louis Cardinals will play on Friday at George M. Steinbrenner Field, at 7:35 p.m. ET, with Junior Caminero and Willson Contreras among those expected to produce at the plate. The favored Rays have -138 moneyline odds against the underdog Cardinals, who are listed at +117. Tampa Bay is the favorite on the run line (-1.5). The total is 9 runs for the game.

Take a look at everything you need from a betting perspective on the Rays-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Rays Highlights | MLB on FOX

Check out the best moments from the St. Louis Cardinals and Tampa Bay Rays.

Rays vs. Cardinals Game Information & Odds

• When: Friday, August 22, 2025 at 7:35 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and FDSMW

Rays vs. Cardinals Prediction

• Score Prediction: Rays 4, Cardinals 3
• Total Prediction: Under 9 runs
• Win Probabilities: Rays 55%, Cardinals 45%

Rays vs. Cardinals Betting Insights

• This season, the Rays have won 35 out of the 61 games, or 57.4%, in which they've been favored.
• Tampa Bay is 16-15 this season when entering a game favored by -138 or more on the moneyline.
• The moneyline for this contest implies a 58% chance of a victory for the Rays.
• The Cardinals have won in 34, or 48.6%, of the 70 contests they have been named as odds-on underdogs this year.
• This season, St. Louis has come away with a win 16 times in 38 chances when named as an underdog of at least +117 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 46.1% chance of pulling out a win.

Rays Recent Betting Performance

• The Rays went 2-1 over the three games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Rays combined with their opponents to go over the total eight times.
• The Rays have gone 3-7-0 against the spread over their past 10 games.

Rays Recent Stats

Rays Player Insights

• Caminero has put up a team-high 35 home runs and 86 runs batted in.
• Among all MLB hitters, Caminero is 88th in batting average, 136th in on-base percentage, and 13th in slugging.
• Caminero brings a hitting streak of two games into this game. During his last five outings he is hitting .105 with three walks and an RBI.
• Yandy Diaz is hitting .281 with 22 doubles, a triple, 21 home runs and 40 walks.
• Of all MLB batters, Diaz ranks 41st in homers and 25th in RBI.
• Brandon Lowe has 13 doubles, 24 home runs and 30 walks while batting .269.
• Chandler Simpson is batting .302 with 11 doubles, two triples and 17 walks.
• Simpson takes a three-game streak with at least one hit into this one. In his last five games he is batting .238 with a double, two walks and an RBI.

Rays Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in six of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Cardinals and their opponents are 6-4-0 when it comes to hitting the over.
• The Cardinals have won four of their last 10 games against the spread.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson leads the Cardinals with a .285 batting average.
• Among all hitters in the majors, Burleson ranks 101st in homers and 71st in RBI.
• Contreras has hit 18 home runs with 68 RBI, leading the team in both categories.
• Contreras is 61st overall in home runs and 44th in RBI this season.
• Masyn Winn is batting .260 with 26 doubles, nine home runs and 31 walks.
• Lars Nootbaar is hitting .244 with 20 doubles, 13 home runs and 50 walks.

Cardinals Team Props

Cardinals vs. Rays Highlights | MLB on FOX

Check out the best moments from the St. Louis Cardinals and Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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