Pirates vs. Guardians Prediction, Odds, Picks - April 19

The Pittsburgh Pirates and Cleveland Guardians play on Saturday at 4:05 p.m. ET. Oneil Cruz and Steven Kwan have been on a tear in recent games for their respective teams. The favored Pirates have -173 moneyline odds to win against the underdog Guardians, who are listed at +145. Pittsburgh is a 1.5-run favorite (at +122 odds). The game's total has been set at 8 runs.

Here is everything you need from a betting perspective on the Pirates-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Pittsburgh Pirates.

Pirates vs. Guardians Game Information & Odds

• When: Saturday, April 19, 2025 at 4:05 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and CLEG

Pirates vs. Guardians Prediction

• Score Prediction: Pirates 5, Guardians 4
• Total Prediction: Under 8 runs
• Win Probabilities: Pirates 53%, Guardians 47%

Pirates vs. Guardians Betting Insights

• This season, the Pirates have won five out of the nine games in which they've been favored.
• Pittsburgh has played as favorites of -173 or more once this season and won that game.
• The Pirates have a 63.4% chance to win this game based on the implied probability of the moneyline.
• The Guardians have been underdogs in 10 games this season and have come away with the win three times (30%) in those contests.
• Cleveland has a mark of 1-2 in contests where oddsmakers favor it by +145 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 40.8% chance of walking away with the win.

Pirates Recent Betting Performance

• The Pirates have a 3-2 record from the five games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Pirates and their opponents combined to hit the over three times.
• The Pirates have gone 3-7-0 against the spread over their past 10 games.

Pirates Recent Stats

Pirates Player Insights

• Cruz is the Pirates best power option, launching five round-trippers this season in addition to accumulating 11 RBI, both team highs.
• In all of MLB, Cruz ranks 18th in home runs and 48th in RBI.
• Cruz has collected a hit in three straight games. In his last five games he is batting .300 with a double, three home runs, two walks and six RBI.
• Isiah Kiner-Falefa's .269 batting average paces his team.
• Kiner-Falefa ranks 253rd in home runs in baseball, and 198th in RBI.
• Kiner-Falefa heads into this game looking for his fourth game in a row with a hit. During his last five outings he is batting .294 with a double and an RBI.
• Ke'Bryan Hayes is hitting .194 with a double, a triple, a home run and seven walks.
• Enmanuel Valdez has four doubles, a triple, a home run and six walks while hitting .233.
• Valdez takes a three-game streak with at least one hit into this one. In his last five games he is hitting .375 with two doubles, a home run, four walks and six RBI.

Pirates Team Props

Guardians Recent Betting Performance

• In four games over the last 10 matchups when set as underdogs by bookmakers, the Guardians had a record of 1-3.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over six times.
• The Guardians have won five of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Kwan paces the Guardians with a .320 batting average.
• In all of the majors, Kwan is 60th in home runs and 48th in RBI.
• Jose Ramirez's four home runs pace his team.
• Ramirez is 34th overall in home runs and 108th in RBI this season.
• Kyle Manzardo has been a significant run producer for the Guardians with four home runs and 12 runs batted in.
• Carlos Santana is batting .260 with two doubles, two home runs and eight walks.

Guardians Team Props

Guardians vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Pittsburgh Pirates.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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