Padres vs. White Sox Prediction, Odds, Picks - September 19

Manny Machado and Andrew Benintendi will look to continue their recent offensive production when the San Diego Padres and Chicago White Sox hit the field at Rate Field on Friday, at 7:40 p.m. ET. The Padres are -190 moneyline favorites for this matchup with the White Sox (+158). San Diego is the run-line favorite (-1.5). The total is 8 runs for this matchup (with -115 odds to hit the over and -105 odds on the under).

Take a look at everything you need from a betting perspective on the Padres-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. White Sox Game Information & Odds

• When: Friday, September 19, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and SDPA

Padres vs. White Sox Prediction

• Score Prediction: Padres 5, White Sox 4
• Total Prediction: Over 8 runs
• Win Probabilities: Padres 50%, White Sox 50%

Padres vs. White Sox Betting Insights

• This season, the Padres have been favored 85 times and won 50, or 58.8%, of those games.
• San Diego has a record of 13-7, a 65% win rate, when favored by -190 or more by bookmakers this season.
• The Padres have a 65.5% chance to win this game based on the implied probability of the moneyline.
• The White Sox have come away with 56 wins in the 150 contests they have been listed as the underdogs in this season.
• This season, Chicago has been victorious 16 times in 58 chances when named as an underdog of at least +158 or longer on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 38.8% chance of walking away with the win.

Padres Recent Betting Performance

• The Padres were the moneyline favorite in seven of their last 10 games, and they went 4-3 in those matchups.
• In their last 10 matchups (all had set totals), the Padres combined with their opponents to hit the over on the run total four times.
• The Padres' record against the spread is 4-6-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. is batting .266 with 27 doubles, two triples, 22 home runs and 88 walks.
• In all of Major League Baseball, Tatis ranks 59th in homers and 94th in RBI.
• Tatis brings a hitting streak of two games into this game. During his last five outings he is hitting .500 with a home run, four walks and two RBIs.
• Machado has hit 26 home runs with 92 runs batted in. Both are team-highs.
• Machado is 39th in home runs in baseball, and 20th in RBI.
• Machado heads into this matchup looking for his sixth game in a row with a hit. In his last five games he is batting .474 with three home runs, two walks and eight RBIs.
• Luis Arraez has racked up a team-best batting average of .287.
• Arraez will look to build on his seven-game hitting in this matchup. During his last 10 games he is hitting .297 with three walks and two RBIs.
• Ramon Laureano is batting .285 with 25 doubles, two triples, 24 home runs and 34 walks.

Padres Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in nine of their past 10 games and won three of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 4-6-0 in their last 10 games with a total.
• The White Sox have a record of 6-4-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .227 with 31 doubles, two triples, 14 home runs and 50 walks, while getting on base at a rate of .308.
• Vargas' home run total places him 144th in the big leagues, and he is 141st in RBI.
• Benintendi's 20 home runs pace his team.
• Benintendi ranks 72nd in home runs and 100th in RBI among all major league hitters this year.
• Lenyn Sosa paces the White Sox with 20 home runs and 70 runs batted in, while posting a club-best batting average of .261.
• Chase Meidroth is batting .269 with 15 doubles, five home runs and 44 walks.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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