Padres vs. Blue Jays Prediction, Odds, Picks - May 22

Bowden Francis will try to control Fernando Tatis Jr. and the San Diego Padres when they square off against his Toronto Blue Jays on Thursday at 1:07 p.m. ET. The Blue Jays have been listed as -102 moneyline underdogs in this matchup against the Padres (-118). San Diego is the favorite on the run line (-1.5 with +143 odds). The over/under is 8.5 runs for this contest.

Here is everything you need from a betting perspective on the Padres-Blue Jays game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the Toronto Blue Jays.

Padres vs. Blue Jays Game Information & Odds

• When: Thursday, May 22, 2025 at 1:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: MLB Network, SNET, and SDPA

Padres vs. Blue Jays Prediction

• Score Prediction: Blue Jays 5, Padres 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Padres 51%, Blue Jays 49%

Padres vs. Blue Jays Betting Insights

• This season, the Padres have won 17 out of the 27 games, or 63%, in which they've been favored.
• San Diego is 16-9 this season when entering a game favored by -118 or more on the moneyline.
• The moneyline for this contest implies a 54.1% chance of a victory for the Padres.
• The Blue Jays have been victorious in 14, or 50%, of the 28 contests they have been chosen as underdogs in this season.
• Toronto has a mark of 10-11 in contests where bookmakers favor it by -102 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Blue Jays have a 50.5% chance of pulling out a win.

Padres Recent Betting Performance

• The Padres have a 3-6 record from the nine games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Padres and their opponents combined to go over the run total five times.
• The Padres have put together a 3-7-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• The Padres' best power option comes in the form of Tatis and his 12-dinger 27-RBI season, both team highs.
• Tatis' home runs rank him ninth in the majors, and he is 45th in RBI.
• Manny Machado's .314 batting average is a team-high mark.
• Machado ranks 180th in home runs in the majors, and 108th in RBI.
• Luis Arraez has seven doubles, three triples, three home runs and nine walks while batting .301.
• Arraez is on an eight-game hitting streak entering this contest. During his last 10 games he is hitting .333 with three doubles, two triples, a walk and three RBIs.
• Xander Bogaerts is batting .242 with nine doubles, three home runs and 22 walks.

Padres Team Props

Blue Jays Recent Betting Performance

• The Blue Jays have played as underdogs in five of their past 10 games and won four of those contests.
• The Blue Jays and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Blue Jays have a record of 7-3-0 ATS over their last 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. is batting .287 with eight doubles, six home runs and 30 walks.
• Guerrero's home run total places him 86th in the big leagues, and he is 89th in RBI.
• Guerrero has collected a hit in three games in a row. During his last five outings he is batting .222 with a home run, three walks and two RBIs.
• Bo Bichette has a club-high 24 RBI and .288 batting average.
• Bichette is currently 149th in homers and 71st in RBI in the big leagues.
• George Springer has 11 doubles, a triple, five home runs and 25 walks while batting .264.
• Alejandro Kirk is hitting .277 with four doubles, three home runs and seven walks.

Blue Jays Team Props

Padres vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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