Guardians vs. Yankees Prediction, Odds, Picks - April 22

Updated Apr. 22, 2025 6:00 p.m. ET

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Kyle Manzardo and the Cleveland Guardians will square off against Aaron Judge and the New York Yankees at Progressive Field in the second of a three-game series, Tuesday at 6:10 p.m. ET. Oddsmakers list the Guardians as -117 favorites on the moneyline, while giving the underdog Yankees -102 moneyline odds to win. New York is the favorite on the run line (-1.5). The over/under for the matchup is listed at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Guardians-Yankees game, regarding the run line, moneyline and total, plus expert picks.

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Yankees' Jazz Chisholm Jr. crushes a two-run homer against the Guardians

New York Yankees' Jazz Chisholm Jr. crushed a two-run homer against the Cleveland Guardians.

Guardians vs. Yankees Game Information & Odds

• When: Tuesday, April 22, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and YES

Guardians vs. Yankees Prediction

• Score Prediction: Yankees 5, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Guardians 53%, Yankees 47%

Guardians vs. Yankees Betting Insights

• The Guardians have entered the game as favorites nine times this season and won seven of those games.
• Cleveland has a record of 6-1 in games when bookmakers favor them by at least -117 on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 53.9% chance to win.
• The Yankees have been victorious in one of the four contests they have been chosen as underdogs in this season.
• New York has yet to win this season when listed as an underdog of -102 or worse on the moneyline this season.
• The moneyline set for this matchup implies the Yankees have a 50.5% chance of coming away with a victory in the contest.

FINAL

NYY 2 · CLE 3

MLB

RUN LINE

TO WIN

TOTAL

New York Yankees

NYY

-1.5

-101

O 8.5

Cleveland Guardians

CLE

+1.5

-119

U 8.5

Guardians Recent Betting Performance

• The Guardians played three of their last 10 games as the moneyline favorite, and won all of them.
• In their last 10 matchups (all 10 of them had set totals), the Guardians and their opponents combined to hit the over six times.
• The Guardians' ATS record is 6-4-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan has a team-high batting average of .333.
• In all of Major League Baseball, Kwan ranks 43rd in home runs and 34th in RBI.
• Kwan carries a five-game hitting streak into this matchup. In his last five games he is batting .400 with two doubles, a home run, three walks and three RBI.
• Jose Ramirez has four doubles, five home runs and eight walks while hitting .276.
• Ramirez is 25th in homers in baseball, and 42nd in RBI.
• Ramirez has four games in a row with at least one hit. In his last five games he is batting .300 with a double, a home run, two walks and five RBI.
• Manzardo has racked up a team-best seven home runs and 17 runs batted in.
• Manzardo has at least one base hit in five straight games. During his last five outings he is batting .333 with a double, three home runs, two walks and six RBI.
• Gabriel Arias is hitting .275 with three doubles, four home runs and five walks.
• Arias brings a three-game streak with at least one hit into this one. In his last five games he is hitting .250 with two doubles, a home run, a walk and three RBI.

Guardians Team Props

Yankees Recent Betting Performance

• Over the past 10 games, the Yankees have been underdogs twice and split those games 1-1.
• In their last 10 games with a total, the Yankees and their opponents have combined to hit the over four times.
• The Yankees have a record of 5-5-0 ATS over their last 10 games.

Yankees Recent Stats

Yankees Player Insights

• Judge paces the Yankees with seven home runs and 25 runs batted in, while recording a team-high batting average of .384.
• Judge's home run total places him fifth in MLB, and he is first in RBI.
• Judge carries a three-game hitting streak into this matchup. In his last five games he is batting .300 with a double, three walks and four RBI.
• Ben Rice is hitting .288 with three doubles, a triple, five home runs and 10 walks.
• Rice ranks 25th in home runs and 116th in RBI among all hitters in the majors.
• Anthony Volpe is batting .217 with five doubles, four home runs and 11 walks.
• Paul Goldschmidt is batting .372 with five doubles, a home run and seven walks.

Yankees Team Props

Guardians vs. Pirates Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Pittsburgh Pirates.

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MLB - New York Yankees vs. Cleveland Guardians - 04/22/2025

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