Guardians vs. White Sox Prediction, Odds, Picks - August 10

The Chicago White Sox and Lenyn Sosa take the field against Steven Kwan and the Cleveland Guardians on Sunday, in the final game of a three-game series at Rate Field. The White Sox are listed as +110 moneyline underdogs in this matchup with the favorite Guardians (-131). Cleveland is the favorite on the run line (-1.5). A 9-run total is listed in the matchup.

Here is everything you need from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and Chicago White Sox.

Guardians vs. White Sox Game Information & Odds

• When: Sunday, August 10, 2025 at 2:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and CLEG

Guardians vs. White Sox Prediction

• Score Prediction: White Sox 5, Guardians 4
• Total Prediction: Under 9 runs
• Win Probabilities: Guardians 51%, White Sox 49%

Guardians vs. White Sox Betting Insights

• This season, the Guardians have been favored 49 times and won 31, or 63.3%, of those games.
• This season Cleveland has won 21 of its 28 games, or 75%, when favored by at least -131 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 56.7%.
• The White Sox have been victorious in 41, or 35.7%, of the 115 contests they have been chosen as underdogs in this season.
• This season, Chicago has come away with a win 40 times in 108 chances when named as an underdog of at least +110 or longer on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 47.6% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians have a 6-1 record from the seven games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Guardians combined with their opponents to go over the total five times.
• The Guardians have a 7-3-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Jose Ramirez lead the Guardians in hitting with his .293 average, he also paces the squad with 23 home runs and 61 RBI.
• Among all hitters in MLB, Ramirez is 19th in home runs and 53rd in RBI.
• Kwan has 21 doubles, a triple, nine home runs and 40 walks while batting .280.
• Of all major league hitters, Kwan is 171st in homers and 161st in RBI.
• Carlos Santana has nine doubles, 11 home runs and 49 walks while batting .229.
• Kyle Manzardo has 14 doubles, two triples, 18 home runs and 36 walks while hitting .241.
• Manzardo is riding a three-game hitting streak into this one. During his last five outings he is hitting .333 with a double, four walks and two RBIs.

Guardians Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won three of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 5-3-2 in their last 10 games with a total.
• The White Sox have a record of 4-6-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Andrew Benintendi has collected a team-high 14 home runs.
• Benintendi's home run total puts him 93rd in the big leagues, and he ranks 126th in RBI.
• Luis Robert has made the most of his opportunities as he paces his team with 46 RBI.
• Robert ranks 119th in homers and 111th in RBI among all batters in the majors.
• Sosa has put up a team-best batting average of .275.
• Mike Tauchman has 13 doubles, a triple, eight home runs and 31 walks while hitting .273.

White Sox Team Props

Guardians vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the Cleveland Guardians and Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Chicago White Sox

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