Guardians vs. Red Sox Prediction, Odds, Picks - April 26

Tanner Houck takes the mound for the Boston Red Sox on Saturday at Progressive Field against Jose Ramirez and the Cleveland Guardians. First pitch is at 1:10 p.m. ET. The Guardians are listed as -110 moneyline favorites in this matchup with the Red Sox (-108). Boston is favored on the run line (-1.5). The over/under for the game has been listed at 8 runs.

Here is everything you need to know from a betting perspective on the Guardians-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Red Sox Game Information & Odds

• When: Saturday, April 26, 2025 at 1:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: Apple TV+

Guardians vs. Red Sox Prediction

• Score Prediction: Guardians 4, Red Sox 3
• Total Prediction: Under 8 runs
• Win Probabilities: Guardians 55%, Red Sox 45%

Guardians vs. Red Sox Betting Insights

• This season, the Guardians have been favored 10 times and won eight of those games.
• Cleveland has a record of 8-2 in games when oddsmakers favor them by at least -110 on the moneyline.
• The moneyline for this contest implies a 52.4% chance of a victory for the Guardians.
• The Red Sox have won in three of the seven contests they have been named as odds-on underdogs this year.
• This season, Boston has come away with a win three times in seven chances when named as an underdog of at least -108 or worse on the moneyline.
• The Red Sox have an implied victory probability of 51.9% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians were named the moneyline favorite by oddsmakers only two times in the last 10 games, and won both matchups.
• In their last 10 outings, the Guardians and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Guardians have gone 5-5-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• The Guardians best hitter so far this season is Steven Kwan, who's hitting at a team-leading .337 clip along with four homers and 14 RBI.
• Of all hitters in MLB, Kwan's home run total places him 51st, and his RBI tally puts him 47th.
• Kwan carries a seven-game hitting streak into this matchup. During his last 10 games he is hitting .350 with two doubles, two home runs, four walks and six RBI.
• Ramirez is batting .265 with four doubles, five home runs and nine walks.
• Ramirez is 34th in homers and 63rd in RBI among all major league hitters this year.
• Kyle Manzardo paces the Guardians in home runs (seven) and runs batted in (18).
• Manzardo is on a six-game hitting streak entering this contest. During his last 10 games he is hitting .212 with two doubles, three home runs, five walks and seven RBI.
• Gabriel Arias is hitting .270 with four doubles, four home runs and five walks.

Guardians Team Props

Red Sox Recent Betting Performance

• The Red Sox have played as underdogs in three of their past 10 games and won two of those contests.
• The Red Sox and their opponents have combined to hit the over six times in their last 10 games with a total.
• The Red Sox are 5-5-0 ATS over their last 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Alexander David Bregman leads the Red Sox with five home runs and 21 runs batted in, while recording a team-high batting average of .320.
• Bregman is 34th in homers and ninth in RBI among all hitters in the big leagues.
• Bregman carries a five-game hitting streak into this matchup. In his last five games he is batting .444 with three doubles, a home run, three walks and five RBI.
• Wilyer Abreu has six doubles, four home runs and 16 walks while hitting .271.
• Abreu ranks 51st overall in home runs and 33rd in RBI this year.
• Jarren Duran has seven doubles, two triples, a home run and eight walks while hitting .250.
• Trevor Story has swatted a team-high five long balls.

Red Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

Boston Red Sox