Guardians vs. Pirates Prediction, Odds, Picks - April 18

Carmen Mlodzinski will take the mound for the Pittsburgh Pirates against Jose Ramirez and the Cleveland Guardians on Friday at 6:40 p.m. ET. The favored Guardians have -131 moneyline odds against the underdog Pirates, who are listed at +111. Cleveland is the favorite on the run line (-1.5). The total is 8.5 runs for this contest (with -121 odds to go over and -100 odds on the under).

Here's everything you need from a betting perspective on the Guardians-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Pirates Game Information & Odds

• When: Friday, April 18, 2025 at 6:40 p.m. ET
• Where: PNC Park in Pittsburgh, Pennsylvania
• How to watch on TV: SportsNet PT and CLEG

Guardians vs. Pirates Prediction

• Score Prediction: Pirates 5, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Guardians 54%, Pirates 46%

Guardians vs. Pirates Betting Insights

• The Guardians have been favorites in eight games this season and won six (75%) of those contests.
• Cleveland has entered five games this season favored by -131 or more and is 4-1 in those contests.
• Oddsmakers have implied with the moneyline set for this matchup that the Guardians have a 56.7% chance to win.
• The Pirates have won in three, or 27.3%, of the 11 contests they have been named as odds-on underdogs this year.
• This season, Pittsburgh has come away with a win one time in seven chances when named as an underdog of at least +111 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Pirates have a 47.4% chance of pulling out a win.

Guardians Recent Betting Performance

• The Guardians have a 5-1 record across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total three times.
• The Guardians have put together a 4-6-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan is the Guardians best hitter, putting together an average of .310 while also being the team's top run producer, delivering 11 RBI and hitting three long balls.
• Including all MLB hitters, Kwan is 24th in batting average, 45th in on-base percentage, and 61st in slugging.
• Jose Ramirez's four home runs lead his team.
• Including all major league hitters, Ramirez is 28th in homers and 99th in RBI.
• Kyle Manzardo paces the Guardians with four home runs and 11 runs batted in.
• Carlos Santana has two doubles, two home runs and seven walks while hitting .261.
• Santana has recorded at least one hit in four games in a row. During his last five outings he is batting .238 with .

Guardians Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs in five of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Pirates and their opponents have failed to hit the over seven times.
• The Pirates have a record of 4-6-0 ATS over their last 10 games.

Pirates Recent Stats

Pirates Player Insights

• Oneil Cruz has a team-leading four home runs and has driven in 10 runs.
• Cruz ranks 28th in home runs and 55th in RBI among all hitters in the majors.
• Isiah Kiner-Falefa's .270 batting average is a team-high mark.
• Kiner-Falefa ranks 250th in homers and 188th in RBI among all MLB hitters this season.
• Ke'Bryan Hayes is hitting .194 with a double, a triple, a home run and seven walks.
• Andrew McCutchen has two doubles, a home run and seven walks while batting .233.

Pirates Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Pittsburgh Pirates

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