Giants vs. Padres Prediction, Odds, Picks - June 2

Heliot Ramos and the San Francisco Giants square off against Manny Machado and the San Diego Padres at Oracle Park on Monday, at 9:45 p.m. ET. The Giants are favored in this one, at -177, while the underdog Padres have +148 odds to win. San Francisco is the run-line favorite (-1.5). The total is 7.5 runs for the matchup (with -101 odds to go over and -119 odds on the under).

Take a look at everything you need from a betting perspective on the Giants-Padres game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Pirates vs. Padres Highlights | MLB on FOX

Check out the best moments between the Pittsburgh Pirates and the San Diego Padres!

Giants vs. Padres Game Information & Odds

• When: Monday, June 2, 2025 at 9:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and SDPA

Giants vs. Padres Prediction

• Score Prediction: Giants 4, Padres 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Giants 56%, Padres 44%

Giants vs. Padres Betting Insights

• This season, the Giants have won 22 out of the 36 games, or 61.1%, in which they've been favored.
• This season San Francisco has won four of its six games when favored by at least -177 on the moneyline.
• The moneyline for this contest implies a 63.9% chance of a victory for the Giants.
• The Padres have won in 12, or 52.2%, of the 23 contests they have been named as odds-on underdogs this year.
• San Diego has played as an underdog of +148 or more just one time this year and came away with a win in that game.
• The Padres have an implied victory probability of 40.3% according to the moneyline set by oddsmakers for this matchup.

Giants Recent Betting Performance

• The Giants have a 3-4 record over the seven games they were favored on the moneyline in their last 10 matchups.
• In their last 10 matchups, the Giants and their opponents combined to go over the run total one time (all 10 of the games had set totals).
• The Giants have gone 3-7-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee is batting .277 with 14 doubles, two triples, six home runs and 15 walks.
• In all of the majors, Lee is 112th in home runs and 50th in RBI.
• Lee carries a two-game hitting streak into this matchup. In his last five games he is hitting .238 with a walk.
• Ramos has shown off his power as he leads his team with 10 home runs with a team-best .295 batting average.
• Ramos ranks 37th in homers and 68th in RBI among all batters in MLB.
• Ramos heads into this game looking for his sixth game in a row with a hit. In his last five games he is hitting .429 with a triple, a home run, two walks and two RBIs.
• Wilmer Flores has a team-high 10 home runs and 47 runs batted in.
• Matt Chapman has shown off his power as he paces his team with 10 home runs.

Giants Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in three of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Padres and their opponents have failed to hit the over six times.
• The Padres have a record of 4-6-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. has swatted a team-high 13 home runs.
• Among all hitters in the majors, Tatis' home run total ranks 13th and his RBI tally is 75th.
• Machado is batting .308 to lead the lineup.
• Among all MLB batters, Machado is 87th in homers and 82nd in RBI.
• Luis Arraez has 11 doubles, three triples, three home runs and 10 walks while hitting .289.
• Gavin Sheets has driven in the most runs for the Padres with 34 runs batted in.

Padres Team Props

Giants vs. Marlins Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Miami Marlins!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco Giants

San Diego Padres