Giants vs. Guardians Prediction, Odds, Picks - June 19

Jose Ramirez and the Cleveland Guardians square off against Mike Yastrzemski and the San Francisco Giants on Thursday at 4:05 p.m. ET at Oracle Park. Bookmakers list the Giants as -153 moneyline favorites, while giving the underdog Guardians +128 moneyline odds. San Francisco is the favorite on the run line (-1.5 with +141 odds). The over/under is 8 runs for the matchup.

Here's everything you need to know from a betting perspective on the Giants-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Giants Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the San Francisco Giants.

Giants vs. Guardians Game Information & Odds

• When: Thursday, June 19, 2025 at 4:05 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and CLEG

Giants vs. Guardians Prediction

• Score Prediction: Giants 4, Guardians 3
• Total Prediction: Under 8 runs
• Win Probabilities: Giants 56%, Guardians 44%

Giants vs. Guardians Betting Insights

• The Giants have won 26, or 57.8%, of the 45 games they've played as favorites this season.
• San Francisco has a record of 10-9, a 52.6% win rate, when favored by -153 or more by sportsbooks this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 60.5% chance to win.
• The Guardians have been victorious in 21, or 46.7%, of the 45 contests they have been chosen as underdogs in this season.
• This year, Cleveland has won five of 14 games when listed as at least +128 or worse on the moneyline.
• The Guardians have an implied victory probability of 43.9% according to the moneyline set for this matchup.

Giants Recent Betting Performance

• The Giants were the moneyline favorite for six of their last 10 games, and they went 3-3 in those matchups.
• In their last 10 outings (all had set totals), the Giants combined with their opponents to go over the run total four times.
• The Giants have gone 4-6-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has racked up a team-best 15 home runs and 59 runs batted in.
• Devers' home runs put him 15th in MLB, and he ranks fifth in RBI.
• Jung Hoo Lee is hitting .261 with 17 doubles, five triples, six home runs and 25 walks.
• Including all major league batters, Lee ranks 155th in homers and 81st in RBI.
• Heliot Ramos leads the Giants with a .284 batting average.
• Wilmer Flores has six doubles, 11 home runs and 23 walks while batting .253.

Giants Team Props

Guardians Recent Betting Performance

• In seven games over the last 10 matchups when set as underdogs by oddsmakers, the Guardians had a record of 3-4.
• The Guardians and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Guardians have a record of 6-4-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez paces the Guardians in home runs (13), runs batted in (35) and has recorded a team-best batting average of .319.
• In all of MLB, Ramirez ranks 29th in homers and 74th in RBI.
• Steven Kwan is batting .293 with 14 doubles, six home runs and 25 walks.
• Kwan is currently 155th in home runs and 165th in RBI in the major leagues.
• Carlos Santana has a team-high 35 runs batted in.
• Kyle Manzardo is hitting .212 with 10 doubles, two triples, 11 home runs and 23 walks.

Guardians Team Props

Guardians vs. Giants Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco Giants

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