Giants vs. Guardians Prediction, Odds, Picks - June 17

Rafael Devers and the San Francisco Giants will look to find success against Slade Cecconi when he starts for the Cleveland Guardians on Tuesday at 9:45 p.m. ET. Oddsmakers list the Giants as -152 moneyline favorites, while giving the underdog Guardians +127 moneyline odds to win. San Francisco (-1.5) is favored on the run line. The over/under is 7 runs for this matchup (with -121 odds to go over and +100 odds on the under).

Here's everything you need to know from a betting perspective on the Giants-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Ken Rosenthal talks Rafael Devers-Giants trade, Shohei Ohtani's pitching debut | First Things First

FOX Sports MLB reporter and insider Ken Rosenthal joins the First Things First crew to break down why the Boston Red Sox traded Rafael Devers to the New York Giants, then previews Shohei Ohtani's pitching debut with the Los Angeles Dodgers against the San Diego Padres.

Giants vs. Guardians Game Information & Odds

• When: Tuesday, June 17, 2025 at 9:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and CLEG

Giants vs. Guardians Prediction

• Score Prediction: Giants 4, Guardians 3
• Total Prediction: Under 7 runs
• Win Probabilities: Giants 57%, Guardians 43%

Giants vs. Guardians Betting Insights

• This season, the Giants have won 26 out of the 43 games, or 60.5%, in which they've been favored.
• San Francisco is 11-8 this season when entering a game favored by -152 or more on the moneyline.
• The moneyline for this contest implies a 60.3% chance of a victory for the Giants.
• The Guardians have been underdogs in 43 games this season and have come away with the win 19 times (44.2%) in those contests.
• Cleveland has a mark of 6-9 in contests where oddsmakers favor it by +127 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 44.1% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants were the moneyline favorite for five of their last 10 games, and they finished 4-1 in those matchups.
• In their last 10 matchups, the Giants and their opponents combined to go over the total five times (all 10 games had set totals).
• The Giants have gone 6-4-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• The Giants' best power option comes in the form of Devers and his 15-home-run 58-RBI season, both team highs.
• Among all hitters in baseball, Devers is 15th in home runs and third in RBI.
• Jung Hoo Lee has 17 doubles, five triples, six home runs and 24 walks while hitting .265.
• Lee ranks 150th in home runs and 69th in RBI on the year.
• Heliot Ramos has put up a team-high batting average of .286.
• Wilmer Flores has six doubles, 11 home runs and 22 walks while hitting .256.

Giants Team Props

Guardians Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Guardians have a record of 1-6.
• When it comes to hitting the over, the Guardians and their opponents are 4-5-1 in their last 10 games with a total.
• Over their last 10 games, the Guardians are 4-6-0 against the spread.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the squad with a batting average of .324, and leads the Guardians in home runs, with 13 and runs batted in with 34.
• Ramirez's home run total puts him 25th in the big leagues, and he ranks 69th in RBI.
• Steven Kwan is hitting .300 with 14 doubles, six home runs and 23 walks.
• Kwan is 150th in homers and 158th in RBI among all batters in the majors.
• Carlos Santana leads the Guardians with 34 runs batted in.
• Kyle Manzardo is batting .208 with eight doubles, two triples, 11 home runs and 23 walks.

Guardians Team Props

Ken Rosenthal talks Rafael Devers-Giants trade, Shohei Ohtani's pitching debut | First Things First

FOX Sports MLB reporter and insider Ken Rosenthal joins the First Things First crew to break down why the Boston Red Sox traded Rafael Devers to the New York Giants, then previews Shohei Ohtani's pitching debut with the Los Angeles Dodgers against the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.