Cubs vs. White Sox Prediction, Odds, Picks - May 17

Kyle Tucker and the Chicago Cubs will play Miguel Vargas and the Chicago White Sox on Saturday at Wrigley Field, at 2:20 p.m. ET. The favored Cubs have -310 moneyline odds against the underdog White Sox, who are listed at +248. The Cubs are a 1.5-run favorite (at -154 odds). The over/under is 10 runs for the game.

Check out everything you need from a betting perspective on the Cubs-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. White Sox Game Information & Odds

• When: Saturday, May 17, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and CHSN

Cubs vs. White Sox Prediction

• Score Prediction: Cubs 5, White Sox 4
• Total Prediction: Under 10 runs
• Win Probabilities: Cubs 61%, White Sox 39%

Cubs vs. White Sox Betting Insights

• The Cubs have won 17, or 65.4%, of the 26 games they've played as favorites this season.
• The Cubs have not entered a game this season with shorter moneyline odds than -310.
• The moneyline for this contest implies a 75.6% chance of a victory for the Cubs.
• The White Sox have been chosen as underdogs in 45 games this year and have walked away with the win 14 times (31.1%) in those games.
• The White Sox have been named as an underdog of +248 or more just one time this season and left with a loss in that game.
• The White Sox have an implied victory probability of 28.7% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs have a 4-3 record from the seven games they were moneyline favorites over their last 10 matchups.
• Over their last 10 matchups, the Cubs and their opponents combined to hit the over on the run total six times (all 10 games had set totals).
• The Cubs' ATS record is 4-6-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Tucker is batting .267 with nine doubles, four triples, 10 home runs and 30 walks.
• Among all MLB batters, Tucker is 60th in batting average, 32nd in on-base percentage, and 15th in slugging.
• Tucker has collected a hit in two games in a row. In his last five games he is hitting .200 with a double, two triples, a walk and an RBI.
• Pete Crow-Armstrong has hit 12 home runs while hitting .282. Both pace his team.
• Crow-Armstrong ranks seventh in homers and fourth in RBI on the season.
• Crow-Armstrong has three straight games with at least one hit. During his last five outings he is batting .421 with three home runs, a walk and nine RBIs.
• Seiya Suzuki has put up a team-best 37 runs batted in.
• Suzuki is on a two-game hitting streak entering this contest. In his last five games he is batting .211 with two doubles, two home runs, a walk and five RBIs.
• Carson Kelly is batting .299 with three doubles, a triple, eight home runs and 21 walks.

Cubs Team Props

White Sox Recent Betting Performance

• In 10 games over the last 10 matchups when set as underdogs by sportsbooks, the White Sox had a record of 4-6.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over eight times.
• The White Sox have six wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Vargas has put up a team-high five home runs and has driven in 19 runs.
• Among all hitters in the big leagues, Vargas is 100th in home runs and 101st in RBI.
• Luis Robert has collected a team-best five home runs.
• Robert ranks 100th in homers and 130th in RBI among all MLB hitters this season.
• Lenyn Sosa leads the White Sox with a team-best batting average of .267.
• Andrew Vaughn has swatted a team-leading five home runs.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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