Cardinals vs. White Sox Prediction, Odds, Picks - June 19

Willson Contreras and the St. Louis Cardinals take on Michael A. Taylor and the Chicago White Sox at Rate Field on Thursday at 5:40 p.m. ET, in the second game of a three-game series. The favored Cardinals have -142 moneyline odds against the underdog White Sox, who are listed at +121. St. Louis is the favorite on the run line (-1.5 with +115 odds). The total is 9 runs for the game.

Check out everything you need to know from a betting perspective on the Cardinals-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. White Sox Game Information & Odds

• When: Thursday, June 19, 2025 at 5:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and FDSMW

Cardinals vs. White Sox Prediction

• Score Prediction: Cardinals 6, White Sox 5
• Total Prediction: Over 9 runs
• Win Probabilities: Cardinals 52%, White Sox 48%

Cardinals vs. White Sox Betting Insights

• This season, the Cardinals have been favored 32 times and won 16, or 50%, of those games.
• St. Louis is 5-2 this season when entering a game favored by -142 or more on the moneyline.
• The implied probability of a win from the Cardinals, based on the moneyline, is 58.7%.
• The White Sox have been underdogs in 73 games this season and have come away with the win 23 times (31.5%) in those contests.
• This year, Chicago has won 20 of 64 games when listed as at least +121 or worse on the moneyline.
• The White Sox have an implied victory probability of 45.2% according to the moneyline set by oddsmakers for this matchup.

Cardinals Recent Betting Performance

• The Cardinals were the moneyline favorite in five of their last 10 games, and they finished 1-4 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Cardinals and their opponents combined to go over the total five times.
• The Cardinals have gone 6-4-0 against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• The Cardinals best hitter thus far this season is Brendan Donovan, who's hitting at a team-leading .323 rate along with four homers and 27 RBI.
• Including all MLB hitters, Donovan ranks sixth in batting average, 10th in on-base percentage, and 56th in slugging.
• Donovan has collected a hit in two straight games. During his last five outings he is hitting .409 with two doubles and an RBI.
• Nolan Arenado has 11 doubles, a triple, eight home runs and 22 walks while batting .244.
• Arenado is 105th in home runs and 66th in RBI among all MLB hitters this season.
• Arenado has seven games in a row with at least one hit. During his last 10 outings he is batting .286 with a double, a home run, two walks and five RBIs.
• Contreras has put up a team-best nine home runs and 45 runs batted in.
• Lars Nootbaar is batting .223 with 12 doubles, eight home runs and 40 walks.

Cardinals Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won three of those contests.
• The White Sox and their opponents have combined to hit the over five times in their last 10 games with a total.
• The White Sox have six wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas leads the White Sox with 10 home runs and 31 runs batted in, while recording a team-high batting average of .242.
• Vargas is 61st in home runs and 93rd in RBI among all hitters in the majors.
• Vargas carries a six-game hitting streak into this matchup. During his last 10 games he is batting .270 with four doubles, a triple, two home runs, five walks and five RBIs.
• Chase Meidroth is batting .276 with five doubles, two home runs and 23 walks.
• Meidroth is 270th in home runs and 309th in RBI among all MLB hitters this season.
• Andrew Benintendi is batting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is batting .190 with eight doubles, six home runs and 26 walks.

White Sox Team Props

Nolan Gorman crushes three-run home run, extending Cardinals' lead over Brewers

Nolan Gorman crushed a three-run home run to extend the St. Louis Cardinals' lead over the Milwaukee Brewers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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