Brewers vs. Cubs NLDS Game 1 Prediction, Odds, Picks - October 4

The NLDS begins on Saturday when the Milwaukee Brewers play host to the Chicago Cubs. Action begins at 2:08 p.m. ET at American Family Field, and can be watched on TBS and HBO Max. The Brewers are -143 moneyline favorites for this matchup with the Cubs (+119). Milwaukee is favored on the run line (-1.5 with +154 odds). The game's total has been set at 7.5 runs.

Check out everything you need to know from a betting perspective on the Brewers-Cubs game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Brewers vs. Padres Highlights | MLB on FOX

Enjoy the best moments between the Milwaukee Brewers and the San Diego Padres.

Brewers vs. Cubs Game Information & Odds

• When: Saturday, October 4, 2025 at 2:08 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: TBS and HBO Max

Brewers vs. Cubs Prediction

• Score Prediction: Brewers 5, Cubs 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Brewers 55%, Cubs 45%

Brewers vs. Cubs Betting Insights

• The Brewers have been favorites in 97 games this season and won 60 (61.9%) of those contests.
• This season Milwaukee has won 34 of its 45 games, or 75.6%, when favored by at least -143 on the moneyline.
• The Brewers have a 58.8% chance to win this game based on the implied probability of the moneyline.
• The Cubs have come away with 18 wins in the 46 contests they have been listed as the underdogs in this season.
• This season, Chicago has come away with a win five times in 14 chances when named as an underdog of at least +119 or longer on the moneyline.
• The moneyline set for this matchup implies the Cubs have a 45.7% chance of coming away with a victory in the contest.

Brewers Recent Betting Performance

• The Brewers went 3-6 across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Brewers and their opponents combined to hit the over three times.
• The Brewers' ATS record is 3-7-0 over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Brice Turang leads the Brewers with a .288 batting average.
• Turang is 105th in homers and 52nd in RBI among all batters in baseball.
• Turang has collected a hit in four straight games. In his last five games he is batting .353 with two doubles, four walks and four RBIs.
• Christian Yelich's 29 home runs and 103 RBI both lead his team.
• Yelich ranks 34th in home runs and 11th in RBI among all major league hitters this year.
• William Contreras is hitting .260 with 28 doubles, 17 home runs and 84 walks.
• Jackson Chourio is hitting .270 with 35 doubles, four triples, 21 home runs and 30 walks.
• Chourio is riding a two-game hitting streak into this one. In his last five games he is hitting .200 with a double, a home run, two walks and an RBI.

Brewers Team Props

Cubs Recent Betting Performance

• The Cubs have been underdogs twice in the last 10 games and lost both contests.
• When it comes to hitting the over, the Cubs and their opponents are 5-5-0 in their last 10 games with a total.
• The Cubs have won seven of their last 10 games against the spread.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker has 25 doubles, four triples, 22 home runs and 87 walks while hitting .266.
• Tucker's home run total places him 65th in the majors, and he is 77th in RBI.
• Nico Hoerner is batting .297 to lead the lineup.
• Among all major league hitters, Hoerner is 264th in homers and 123rd in RBI.
• Pete Crow-Armstrong is batting .247 with 37 doubles, four triples, 31 home runs and 29 walks.
• Michael Busch paces the Cubs with 34 home runs.

Cubs Team Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Milwaukee Brewers

Chicago Cubs