Blue Jays vs. White Sox Prediction, Odds, Picks - June 21

Miguel Vargas and the Chicago White Sox match up with Alejandro Kirk and the Toronto Blue Jays on Saturday at 3:07 p.m. ET at Rogers Centre. The Blue Jays are -211 moneyline favorites for this matchup with the White Sox (+173). Toronto is the run-line favorite (-1.5). The over/under is 8 runs for this game (with -119 odds to go over and -101 odds to go under).

Here's everything you need from a betting perspective on the Blue Jays-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Blue Jays Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and Toronto Blue Jays.

Blue Jays vs. White Sox Game Information & Odds

• When: Saturday, June 21, 2025 at 3:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: SNET and CHSN

Blue Jays vs. White Sox Prediction

• Score Prediction: Blue Jays 5, White Sox 4
• Total Prediction: Over 8 runs
• Win Probabilities: Blue Jays 56%, White Sox 44%

Blue Jays vs. White Sox Betting Insights

• This season, the Blue Jays have won 16 out of the 28 games, or 57.1%, in which they've been favored.
• Toronto has played as favorites of -211 or more once this season and won that game.
• Oddsmakers have implied with the moneyline set for this matchup that the Blue Jays have a 67.8% chance to win.
• The White Sox have come away with 24 wins in the 76 contests they have been listed as the underdogs in this season.
• Chicago has a win-loss record of 6-26 when favored by +173 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the White Sox have a 36.6% chance of coming away with a victory in the contest.

Blue Jays Recent Betting Performance

• The Blue Jays went 2-2 over the four games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Blue Jays and their opponents combined to hit the over five times (all 10 of the games had set totals).
• The Blue Jays' ATS record is 4-6-0 over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. is batting .282 with 16 doubles, nine home runs and 43 walks.
• Including all MLB hitters, Guerrero is 35th in batting average, 13th in on-base percentage, and 73rd in slugging.
• Bo Bichette's 10 home runs and 45 RBI both pace his team.
• Bichette is 65th in home runs and 25th in RBI among all hitters in MLB.
• George Springer has a team-best 10 homers.
• Kirk has a club-high .313 batting average.

Blue Jays Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and have gone 2-8 in those contests.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over six times.
• The White Sox have a record of 6-4-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas paces the White Sox with 10 home runs and 32 runs batted in, while posting a team-high batting average of .238.
• Among all batters in MLB, Vargas ranks 65th in home runs and 96th in RBI.
• Andrew Benintendi is batting .250 with nine doubles, two triples, eight home runs and 15 walks.
• Benintendi is 110th among all batters in the majors in homers, and 114th in RBI.
• Chase Meidroth is hitting .268 with five doubles, two home runs and 25 walks.
• Luis Robert has eight doubles, seven home runs and 26 walks while batting .191.

White Sox Team Props

White Sox vs. Blue Jays Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and Toronto Blue Jays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Toronto Blue Jays

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