Astros vs. Red Sox Prediction, Odds, Picks - August 13

The Houston Astros will send a hot-hitting Jose Altuve to the plate against the Boston Red Sox and Alex Bregman, who has been on a tear as of late, when the teams meet on Wednesday at 7:10 p.m. ET. Oddsmakers list the Astros as -111 moneyline favorites, while giving the underdog Red Sox -108 moneyline odds. Boston is the run-line favorite (-1.5). The total for the matchup is listed at 9 runs.

Here is everything you need from a betting perspective on the Astros-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Astros' Jose Altuve hammers home run to tie game vs. Rangers

Houston Astros' Jose Altuve hammered home run to tie game vs. the Texas Rangers.

Astros vs. Red Sox Game Information & Odds

• When: Wednesday, August 13, 2025 at 7:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and NESN

Astros vs. Red Sox Prediction

• Score Prediction: Astros 5, Red Sox 4
• Total Prediction: Under 9 runs
• Win Probabilities: Astros 52%, Red Sox 48%

Astros vs. Red Sox Betting Insights

• The Astros have entered the game as favorites 81 times this season and won 43, or 53.1%, of those games.
• Houston has a record of 43-38 in games when bookmakers favor them by at least -111 on the moneyline.
• The implied probability of a win from the Astros, based on the moneyline, is 52.6%.
• The Red Sox have been victorious in 22, or 47.8%, of the 46 contests they have been chosen as underdogs in this season.
• Boston has a mark of 21-22 in contests where sportsbooks favor it by -108 or worse on the moneyline.
• The moneyline set for this matchup implies the Red Sox have a 51.9% chance of coming away with a victory in the contest.

Astros Recent Betting Performance

• The Astros were favored on the moneyline for four of their last 10 games, and they finished 1-3 in those matchups.
• In their last 10 outings, the Astros and their opponents combined to go over the run total eight times (all 10 of the games had set totals).
• The Astros have put together a 5-5-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Altuve has launched a team-best 21 home runs.
• Among all hitters in MLB, Altuve's home run total places him 33rd, and his RBI tally ranks him 51st.
• Jeremy Pena is hitting .318 to lead his team.
• Pena is 125th in homers and 134th in RBI among all batters in the majors.
• Pena carries a two-game streak with at least one hit into this contest. In his last five games he is hitting .227 with a home run, a walk and an RBI.
• Yainer Diaz has 16 doubles, a triple, 16 home runs and 15 walks while batting .251.
• Christian Walker has capitalized on opportunities as he leads his team with 65 RBI.

Astros Team Props

Red Sox Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Red Sox have a record of 3-2.
• In their last 10 games with a total, the Red Sox and their opponents are 9-1-0 when it comes to hitting the over.
• The Red Sox have seven wins against the spread in their last 10 chances.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran paces the Red Sox with a .265 batting average.
• Among all hitters in the big leagues, Duran's home run total is 125th and his RBI tally ranks 41st.
• Ceddanne Rafaela is hitting .259 with 24 doubles, three triples, 14 home runs and 20 walks.
• Rafaela ranks 98th in home runs and 93rd in RBI among all hitters in the majors.
• Trevor Story has racked up a team-best 75 runs batted in.
• Wilyer Abreu has swatted a team-leading 21 home runs.

Red Sox Team Props

Astros' Jose Altuve hammers home run to tie game vs. Rangers

Houston Astros' Jose Altuve hammered home run to tie game vs. the Texas Rangers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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