Angels vs. White Sox Prediction, Odds, Picks - March 27

The Los Angeles Angels and Chicago White Sox will send Yusei Kikuchi and Sean Burke to the hill, respectively, on Opening Day at Rate Field. First pitch is at 4:10 p.m. ET. Oddsmakers list the Angels as -163 favorites on the moneyline, while giving the underdog White Sox +137 moneyline odds to win. Los Angeles is favored on the run line (-1.5). The total is 7.5 runs for the game (with -114 odds on the over and -106 odds to go under).

Check out everything you need from a betting perspective on the Angels-White Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Mariners vs. Angels Highlights | MLB on FOX

Check out the top moments between the Seattle Mariners and the Los Angeles Angels.

Angels vs. White Sox Game Information & Odds

• When: Thursday, March 27, 2025 at 4:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to Watch on TV: CHSN and FDSW

Angels vs. White Sox Prediction

• Score Prediction: Angels 5, White Sox 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Angels 50%, White Sox 50%

Angels vs. White Sox Betting Insights

• The Angels won nine of the 29 games they were favored on the moneyline last season (31%).
• Los Angeles played as a moneyline favorite of -163 or shorter in only one game last season, which it lost.
• Based on this game's moneyline, the Angels' implied win probability is 62%.
• The White Sox won 37, or 24%, of the 154 games they played as underdogs last season.

Angels Player Insights

• Zachary Neto drove in 77 runs while batting .249 last season.
• Taylor Ward slugged 25 long balls while driving in 75 runs.
• Jorge Soler finished last season with 21 home runs, 64 RBI and a batting average of .241.
• Nolan Schanuel posted a .250 average with 54 RBI.

Angels Team Props

White Sox Player Insights

• Andrew Vaughn had 70 runs batted in while racking up a batting average of .246 last season.
• Andrew Benintendi hit 20 home runs on the season while slugging .396.
• Mike Tauchman hit .248 last season with 12 doubles, a triple, seven home runs and 47 walks.
• Josh Rojas hit .225 with 19 doubles, two triples, eight home runs and 46 walks.

White Sox Team Props

Mariners vs. Angels Highlights | MLB on FOX

Check out the top moments between the Seattle Mariners and the Los Angeles Angels.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago White Sox

Los Angeles Angels