USC vs. Illinois Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 9:04 a.m. ET

Data Skrive

The Illinois Fighting Illini (3-1) are 6.5-point underdogs in a home conference matchup with the USC Trojans (4-0) on Saturday, September 27, 2025 at Memorial Stadium (Champaign, IL). The game's point total is 61.

Last time out, the Trojans defeated the Michigan State Spartans, with 45-31 being the final score. In their last contest, the Fighting Illini lost against the Indiana Hoosiers, 63-10.

Keep up with college football all season on FOX Sports.

USC looks for a 5-0 start as they travel to Illinois | Joel Klatt Show

Joel Klatt previewed the USC Trojans travel to take on the Illinois Fighting Illini. He analyzed why USC’s QB Jayden Maiava could be on the short list for the Heisman trophy. Joel also explained how Illinois is trying to bounce back after their loss to Indiana while fighting injuries.

USC vs. Illinois Game Information & Odds

When: Saturday, September 27, 2025 at 12 p.m. ET
Location: Memorial Stadium (Champaign, IL) in Champaign, Illinois
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

USC vs Illinois Betting Information updated as of September 27, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-6.5 (-115)	-248	+202	61	-110	-110

USC vs. Illinois Prediction

Pick ATS: Illinois (+6.5)
Pick OU: Over (61)
Prediction: Illinois 38, USC 27

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the Illinois Fighting Illini game on FOX Sports!

USC vs. Illinois Betting Insights

Per the spread and over/under, the implied score for the tilt is Trojans 34, Fighting Illini 27.
The Trojans have a 71.3% chance to claim victory in this game based on the moneyline's implied probability. The Fighting Illini hold a 33.1% implied probability.
USC has covered twice in four chances against the spread this season.
Illinois is 3-1-0 ATS this year.

USC vs. Illinois: 2025 Stats Comparison

	USC	Illinois
Off. Points per Game (Rank)	52.5 (5)	36.3 (30)
Def. Points per Game (Rank)	20.3 (57)	21.3 (63)
Turnovers Allowed (Rank)	3 (30)	1 (5)
Turnovers Forced (Rank)	7 (14)	6 (27)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	1,223 YDS (70.8%) / 9 TD / 0 INT 55 RUSH YDS / 4 RUSH TD / 13.8 RUSH YPG
Makai Lemon	WR	24 REC / 438 YDS / 3 TD / 109.5 YPG
Waymond Jordan	RB	443 YDS / 3 TD / 110.8 YPG / 7.8 YPC
Eli Sanders	RB	250 YDS / 2 TD / 62.5 YPG / 6.4 YPC 6 REC / 105 REC YDS / 1 REC TD / 26.3 REC YPG
Eric Gentry	LB	16 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	9 TKL / 0 TFL / 3 INT / 3 PD
Braylan Shelby	DL	5 TKL / 3 TFL / 3.5 SACK
Kameryn Fountain	DL	5 TKL / 3 TFL / 2.5 SACK

Illinois 2025 Key Players

Name	Position	Stats
Luke Altmyer	QB	855 YDS (70%) / 9 TD / 0 INT -39 RUSH YDS / 1 RUSH TD / -9.8 RUSH YPG
Hank Beatty	WR	21 REC / 302 YDS / 1 TD / 75.5 YPG
Kaden Feagin	RB	240 YDS / 3 TD / 60 YPG / 4.4 YPC
Ca'Lil Valentine	RB	169 YDS / 2 TD / 42.3 YPG / 5.5 YPC
Gabe Jacas	LB	11 TKL / 1 TFL / 3.5 SACK
Matthew Bailey	DB	22 TKL / 0 TFL
Malachi Hood	LB	17 TKL / 1 TFL
Leon Lowery	LB	10 TKL / 3 TFL / 2 SACK