Penn State vs. UCLA Prediction, Odds, Picks - October 4, 2025

The No. 7 Penn State Nittany Lions (3-1) are 24.5-point favorites when they visit the UCLA Bruins (0-4) in a Big Ten matchup on Saturday, October 4, 2025 at the Rose Bowl. The point total is set at 48.5 for the game.

In their most recent action, the Nittany Lions lost versus the Oregon Ducks, 30-24. The Bruins lost to the Northwestern Wildcats, 17-14, in their last game.

Keep up with college football all season on FOX Sports.

Penn State vs. UCLA Game Information & Odds

• When: Saturday, October 4, 2025 at 3:30 p.m. ET
• Location: Rose Bowl in Pasadena, California
• TV: CBS
• Live Box Score on FOX Sports

Penn State vs. UCLA Prediction

• Pick ATS: UCLA (+24.5)
  
• Pick OU: Under (48.5)
  
• Prediction: Penn State 33, UCLA 14

Predictions are made by the Data Skrive betting model.

Learn more about the Penn State Nittany Lions vs. the UCLA Bruins game on FOX Sports!

Penn State vs. UCLA Betting Insights

• Per the spread and over/under, the implied score for the game is Nittany Lions 36, Bruins 12.
• The Nittany Lions have a 96.3% chance to collect the win in this game based on the moneyline's implied probability. The Bruins have a 7.4% implied probability.
• Penn State is winless against the spread this season (0-4-0).
• UCLA has won one game against the spread this year.

Penn State vs. UCLA: 2025 Stats Comparison

Penn State 2025 Key Players

UCLA 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.