Ole Miss vs. South Carolina Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

FOX Sports

The No. 7 Ole Miss Rebels (7-1) are 12.5-point favorites when they host the South Carolina Gamecocks (3-5) in an SEC matchup on Saturday, November 1, 2025 at Vaught-Hemingway Stadium. The total is 55.5 points for this game.

The Rebels won versus the Oklahoma Sooners in their last game, 34-26. Facing the Alabama Crimson Tide in their last game, the Gamecocks lost 29-22.

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Ole Miss vs. South Carolina Game Information & Odds

When: Saturday, November 1, 2025 at 7 p.m. ET
Location: Vaught-Hemingway Stadium in Oxford, Mississippi
TV: ESPN
Live Box Score on FOX Sports

Ole Miss vs South Carolina Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ole Miss	-12.5 (-110)	-488	+369	55.5	-110	-110

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Ole Miss vs. South Carolina Prediction

Pick ATS: Ole Miss (-12.5)
Pick OU: Under (55.5)
Prediction: Ole Miss 34, South Carolina 16

Predictions are made by the Data Skrive betting model.

Learn more about the Ole Miss Rebels vs. the South Carolina Gamecocks game on FOX Sports!

Ole Miss vs. South Carolina Betting Insights

Based on the spread and over/under, the implied score for the tilt is Rebels 34, Gamecocks 22.
The Rebels have an 83.0% chance to win this meeting based on the moneyline's implied probability. The Gamecocks hold a 21.3% implied probability.
Ole Miss has compiled a 5-3-0 ATS record so far this year.
South Carolina has covered four times in eight games with a spread this season.

Ole Miss vs. South Carolina: 2025 Stats Comparison

	Ole Miss	South Carolina
Off. Points per Game (Rank)	37 (15)	20.4 (116)
Def. Points per Game (Rank)	23 (59)	21.1 (46)
Turnovers Allowed (Rank)	8 (37)	10 (68)
Turnovers Forced (Rank)	5 (123)	14 (20)

Ole Miss 2025 Key Players

Name	Position	Stats
Trinidad Chambliss	QB	1,864 YDS (61%) / 9 TD / 1 INT 376 RUSH YDS / 5 RUSH TD / 47 RUSH YPG
Kewan Lacy	RB	696 YDS / 12 TD / 87 YPG / 4.2 YPC 18 REC / 114 REC YDS / 0 REC TD / 16.3 REC YPG
Dae'Quan Wright	TE	22 REC / 404 YDS / 3 TD / 50.5 YPG
Harrison Wallace III	WR	26 REC / 464 YDS / 2 TD / 58 YPG
Zxavian Harris	DL	32 TKL / 6 TFL / 3 SACK / 1 INT
T.J. Dudley	LB	47 TKL / 1 TFL
Kam Franklin	DL	34 TKL / 1 TFL / 2.5 SACK
William Echoles	DL	30 TKL / 4 TFL / 3 SACK

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	1,356 YDS (63.2%) / 6 TD / 3 INT 175 RUSH YDS / 2 RUSH TD / 21.9 RUSH YPG
Rahsul Faison	RB	298 YDS / 3 TD / 37.3 YPG / 4.3 YPC 15 REC / 88 REC YDS / 0 REC TD / 12.6 REC YPG
Nyck Harbor	WR	18 REC / 332 YDS / 3 TD / 41.5 YPG
Vandrevius Jacobs	WR	21 REC / 343 YDS / 2 TD / 49 YPG
Bryan Thomas Jr.	DL	23 TKL / 6 TFL / 5 SACK
Dylan Stewart	DL	27 TKL / 9 TFL / 4 SACK
Fred Johnson	LB	33 TKL / 3 TFL / 1 SACK / 1 INT
DQ Smith	DB	40 TKL / 0 TFL / 1 INT / 1 PD