Marshall vs. Louisiana Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

FOX Sports

The Louisiana Ragin' Cajuns (1-3) are slight, 2.5-point underdogs in a home Sun Belt matchup against the Marshall Thundering Herd (2-2) on Saturday, September 27, 2025 at Cajun Field at Our Lady of Lourdes Stadium. The point total is 48.5 for the outing.

The Thundering Herd beat the Middle Tennessee Blue Raiders, 42-28, in their last contest. The Ragin' Cajuns' last contest was against the Eastern Michigan Eagles, and they lost by a score of 34-31.

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Marshall vs. Louisiana Game Information & Odds

When: Saturday, September 27, 2025 at 8 p.m. ET
Location: Cajun Field at Our Lady of Lourdes Stadium in Lafayette, Louisiana
TV: ESPN+
Live Box Score on FOX Sports

Marshall vs Louisiana Betting Information updated as of September 27, 2025, 2:46 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Marshall	-2.5 (-108)	-125	+105	48.5	-105	-116

Marshall vs. Louisiana Prediction

Pick ATS: Louisiana (+2.5)
Pick OU: Over (48.5)
Prediction: Louisiana 27, Marshall 26

Predictions are made by the Data Skrive betting model.

Learn more about the Marshall Thundering Herd vs. the Louisiana Ragin' Cajuns game on FOX Sports!

Marshall vs. Louisiana Betting Insights

Based on the spread and over/under, the implied score for the matchup is Thundering Herd 26, Ragin' Cajuns 23.
The Thundering Herd have a 55.6% chance to win this game per the moneyline's implied probability. The Ragin' Cajuns hold a 48.8% implied probability.
Marshall has put together a 3-1-0 ATS record so far this year.
Louisiana is winless against the spread this year (0-3-0).

Marshall vs. Louisiana: Head-to-Head

Louisiana has a 2-1 record against Marshall in their last three matchups.
The last three times the Ragin' Cajuns have played the Thundering Herd, they have a 2-1 record against the spread. The scoring has gone over the point total on one occasion.
Over their last three head-to-head contests, Marshall has put up 65 points, while Louisiana has posted 62.

Marshall vs. Louisiana: 2025 Stats Comparison

	Marshall	Louisiana
Off. Points per Game (Rank)	26.8 (77)	21.8 (100)
Def. Points per Game (Rank)	25.3 (87)	27.5 (105)
Turnovers Allowed (Rank)	4 (50)	4 (50)
Turnovers Forced (Rank)	4 (75)	4 (75)

Marshall 2025 Key Players

Name	Position	Stats
Carlos Del Rio-Wilson	QB	379 YDS (79.4%) / 6 TD / 0 INT 84 RUSH YDS / 2 RUSH TD / 28 RUSH YPG
Justin Williams-Thomas	RB	110 YDS / 2 TD / 27.5 YPG / 4.6 YPC 3 REC / 41 REC YDS / 1 REC TD / 41 REC YPG
Demarcus Lacey	WR	10 REC / 129 YDS / 1 TD / 43 YPG
Toby Payne	TE	9 REC / 107 YDS / 2 TD / 26.8 YPG
Cameron Smith	DB	12 TKL / 3 TFL / 2 SACK
Jabreel Al-Amin	LB	9 TKL / 1 TFL / 1.5 SACK
Jamaal Whyce	DL	5 TKL / 2 TFL / 2.5 SACK
DeWain Trotter	DB	7 TKL / 0 TFL / 2 INT / 2 PD

Louisiana 2025 Key Players

Name	Position	Stats
Zylan Perry	RB	336 YDS / 3 TD / 84 YPG / 7.5 YPC
Elijah Davis	RB	269 YDS / 3 TD / 67.3 YPG / 5.7 YPC
Steven Blanco	RB	115 YDS / 1 TD / 38.3 YPG / 7.2 YPC
Shelton Sampson Jr.	WR	8 REC / 150 YDS / 0 TD / 37.5 YPG
Jaden Dugger	LB	26 TKL / 3 TFL / 1 SACK
Terrence Williams	LB	20 TKL / 2 TFL / 1 SACK
Trae Tomlinson	DB	13 TKL / 1 TFL / 1 SACK
Jalen Clark	DB	14 TKL / 1 TFL / 1 INT / 1 PD