Indiana vs. Illinois Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

Oddsmakers give the No. 19 Indiana Hoosiers (3-0) the edge when they host the No. 9 Illinois Fighting Illini (3-0) on Saturday, September 20, 2025 in a matchup between Big Ten foes at Memorial Stadium (Bloomington, IN). Indiana is favored by a touchdown. A 52.5-point over/under is set for the contest.

The Hoosiers' last game was against the Indiana State Sycamores, and they won by a score of 73-0. The Fighting Illini's last contest was versus the Western Michigan Broncos, and they won by a score of 38-0.

Keep up with college football all season on FOX Sports.

Western Michigan Broncos vs. No. 9 Illinois Fighting Illini Highlights | FOX College Football

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Indiana vs. Illinois Game Information & Odds

When: Saturday, September 20, 2025 at 7:30 p.m. ET
Location: Memorial Stadium (Bloomington, IN) in Bloomington, Indiana
TV: NBC
Live Box Score on FOX Sports

Indiana vs Illinois Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Indiana	-7 (-105)	-260	+211	52.5	-110	-110

Indiana vs. Illinois Prediction

Pick ATS: Indiana (-7)
Pick OU: Under (52.5)
Prediction: Indiana 31, Illinois 21

Predictions are made by the Data Skrive betting model.

Learn more about the Indiana Hoosiers vs. the Illinois Fighting Illini game on FOX Sports!

Indiana vs. Illinois Betting Insights

Per the spread and over/under, the implied score for the tilt is Hoosiers 30, Fighting Illini 23.
The Hoosiers have a 72.2% chance to collect the win in this meeting based on the moneyline's implied probability. The Fighting Illini hold a 32.2% implied probability.
Indiana has a record of 2-1-0 against the spread this season.
Illinois has covered three times in three games with a spread this year.

Indiana vs. Illinois: Head-to-Head

Indiana and Illinois have been matched up evenly over their last two meetings, sharing the same 1-1 record.
The last two times the Hoosiers have matched up against the Fighting Illini, they have a 2-0 record against the spread. The scoring has gone over the point total on one occasion.
Indiana and Illinois have matched up evenly on offense over their past two matchups, with each team producing 68 points in those games.

Indiana vs. Illinois: 2025 Stats Comparison

	Indiana	Illinois
Off. Points per Game (Rank)	52 (6)	45 (13)
Def. Points per Game (Rank)	7.7 (8)	7.3 (7)
Turnovers Allowed (Rank)	1 (10)	0 (1)
Turnovers Forced (Rank)	5 (26)	6 (14)

Indiana 2025 Key Players

Name	Position	Stats
Fernando Mendoza	QB	708 YDS (72.4%) / 9 TD / 0 INT 72 RUSH YDS / 2 RUSH TD / 24 RUSH YPG
Omar Cooper Jr.	WR	13 REC / 299 YDS / 4 TD / 99.7 YPG
Elijah Sarratt	WR	15 REC / 164 YDS / 3 TD / 54.7 YPG
Kaelon Black	RB	217 YDS / 1 TD / 72.3 YPG / 6.4 YPC
Louis Moore	DB	10 TKL / 2 TFL / 2 INT / 2 PD
Isaiah Jones	LB	7 TKL / 4 TFL / 2 SACK
Aiden Fisher	LB	9 TKL / 3 TFL / 1 SACK
D'Angelo Ponds	DB	6 TKL / 2 TFL / 1 INT / 1 PD

Illinois 2025 Key Players

Name	Position	Stats
Luke Altmyer	QB	709 YDS (71.8%) / 8 TD / 0 INT -12 RUSH YDS / 1 RUSH TD / -4 RUSH YPG
Hank Beatty	WR	19 REC / 289 YDS / 1 TD / 96.3 YPG
Kaden Feagin	RB	222 YDS / 3 TD / 74 YPG / 4.4 YPC 2 REC / 13 REC YDS / 0 REC TD / 13 REC YPG
Ca'Lil Valentine	RB	158 YDS / 2 TD / 52.7 YPG / 6.3 YPC
Gabe Jacas	LB	8 TKL / 1 TFL / 3.5 SACK
Matthew Bailey	DB	12 TKL / 0 TFL
Malachi Hood	LB	14 TKL / 1 TFL
Miles Scott	DB	13 TKL / 1 TFL