Mahomes, banged-up Chiefs face Denver on short rest
On defense, Kansas City was without defensive tackle Chris Jones (groin) and defensive back Kendall Fuller, who broke his thumb in a 31-24 loss to Houston last weekend.
Wide receiver Emmanuel Sanders was active for Denver. He has been bothered by a sore knee and left a 16-0 victory over Tennessee last Sunday.
Right tackle Ja'Wuan James missed his sixth straight game after hurting his left knee in the opener. Receiver Juwann Winfree also was inactive along with cornerback Bryce Callahan, linebacker Corey Nelson, tight end Troy Fumagalli, tackle Calvin Anderson and defensive end Adam Gotsis.
The Broncos haven't beaten the Chiefs since 2015 when Peyton Manning was under center.