SEPTEMBER 22 • NINERNOISE.COM
Dominick Puni lauded Mac Jones after costly gaffe in 49ers win vs. Cardinals Dominick Puni shared what went down after he committed a costly penalty that nearly resulted in the 49ers losing Week 3 to the Cardinals.
C.J. West - Requires surgery on thumb Head coach Kyle Shanahan relayed Monday that West will need to undergo surgery to repair a broken thumb, Eric Branch of the San Francisco Chronicle reports.
Impact Despite the necessity of a procedure, Shanahan noted that West could play through the injury with a cast on his broken thumb, which means he has not been ruled out for the 49ers' Week 4 clash against the Jaguars this Sunday, per Branch. West logged two tackles (one solo) in Sunday's 16-15 win over the Cardinals.
SEPTEMBER 22 • ROTOWIRE
Mykel Williams - Deemed day-to-day Williams is considered day-to-day due to a wrist injury, Nick Wagoner of ESPN.com reports.
Impact Williams hurt his wrist in Sunday's Week 3 win over the Cardinals but was able to finish the game after initially being labeled as questionable to return. He logged 65 percent of the 49ers' defensive snaps in the victory and finished with two tackles. Given that he was able to return after getting hurt, there's reason to be optimistic that Williams will be able to suit up Sunday against Jacksonville, though his level of participation in practice this week should provide better insight into whether he'll have an injury designation heading into the weekend.
SEPTEMBER 22 • ROTOWIRE
James Conner Injury Update: Cardinals Coach Confirms Veteran RB Will Miss Rest of Season Jonathan Gannon confirmed James Conner needs surgery on his right leg and will miss the rest of the 2025 season.
SEPTEMBER 22 • SI.COM
49ers Get Encouraging Update on Brock Purdy Amid Injury Absence Finally, some positive injury news for the 49ers.
SEPTEMBER 22 • SI.COM
Renardo Green - Dealing with neck issue Green is managing a neck injury and is considered day-to-day, Nick Wagoner of ESPN.com reports.
Impact Green presumably picked up the issue during Sunday's Week 3 win over Arizona, during which he logged 57 of San Francisco's 66 defensive snaps and finished with four tackles. The cornerback's practice participation level this week should provide more insight about his likelihood of suiting up Sunday versus Jacksonville. If Green can't play in that game, Darrell Luter could be in line for a larger role.
SEPTEMBER 22 • ROTOWIRE
Jauan Jennings - Considered 'day-to-day' Coach Kyle Shanahan said Monday that Jennings (shoulder/ankle) is considered "day-to-day," Nick Wagoner of ESPN.com reports.
Impact Jennings was able to play Week 2 with a shoulder injury that he suffered in the season opener, but he emerged from the second contest with an ankle issue that didn't allow him to practice last week. He was listed as questionable for Sunday's game against the Cardinals but eventually was ruled out. Wednesday's session will mark Jennings' next chance to get his first on-field work since Week 1.
SEPTEMBER 22 • ROTOWIRE
FOX FACTS
3
MILESTONE
Kyler Murray has reached 20,000 passing yards in his career. Heading into today, 120 other players in NFL history (15 active) have reached that mark.
STAT HIGH
Ricky Pearsall has set his season high with 117 receiving yards. His previous season high was 108 receiving yards.
STAT HIGH
Ricky Pearsall has set his season high with 8 receptions. His previous season high was 4 receptions.
STANDINGS
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Arizona Cardinals
San Francisco 49ers
EVENT INFO
Levi's Stadium
Santa Clara, CA
Sep 21, 2025
70,414
2 Hours 55 Minutes
