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San Francisco 49ers vs. Indianapolis Colts - Odds: Dec 23, 2025
49ers
10-4
10-4
DEC 23, 1:15AM
ESPN
8-6
Colts
8-6
MATCHUP
ODDS
MATCHUP ODDS
SPREAD
TO WIN
TOTAL
San Francisco 49ers
SF
-5.5
-260
O 46.5
Indianapolis Colts
IND
+5.5
+211
U 46.5
CHANCE TO WIN
Team to win likelihood based on moneyline
SF 69%
-260
IND 31%
+211
SPREAD
The 49ers must win by 6 points or more to cover the spread
-5.5
SF
+5.5
IND
SPREAD BREAKDOWN
Bets and money are in the majority towards the 49ers.
SF
60%
% OF BETS PLACED
IND
40%
SF
57%
% OF MONEY WAGERED
IND
43%
TEAM TO WIN
A bet of $260 would win $360 total if the 49ers win and a bet of $100 would win $311 total if the Colts win
-260
SF
+211
IND
TEAM TO WIN BREAKDOWN
Bets and money are in the vast majority towards the 49ers.
SF
89%
% OF BETS PLACED
IND
11%
SF
91%
% OF MONEY WAGERED
IND
9%
TOTAL
The combined final score of both teams is set at 46.5
-109
OVER 46.5
-111
UNDER 46.5
TOTAL BREAKDOWN
Bets and money are in the majority towards the Under.
OVER
40%
% OF BETS PLACED
UNDER
60%
OVER
41%
% OF MONEY WAGERED
UNDER
59%
PROPS
PLAYER PASSING YARDS (TOTAL)
How many passing yards will these players have in their next game? Select a player to see potential winnings.
SF at IND Tue 1:15 AM
B. Purdy
240.3 Pass Yds/G
Bet $10 to win
$19 total
OVER
243.5
-114
PROPS
PLAYER PASSING TDS (TOTAL)
How many passing touchdowns will these players have in their next game? Select a player to see potential winnings.
SF at IND Tue 1:15 AM
B. Purdy
12 Pass TD
Bet $10 to win
$16 total
OVER
1.5
-166
PROPS
PLAYER PASSING ATTEMPTS (TOTAL)
How many passing attempts will these players have in their next game? Select a player to see potential winnings.
SF at IND Tue 1:15 AM
B. Purdy
31.7 Pass Att/G
Bet $10 to win
$19 total
OVER
33.5
-108
PROPS
PLAYER PASS COMPLETIONS (TOTAL)
How many passing completions will these players have in their next game? Select a player to see potential winnings.
SF at IND Tue 1:15 AM
B. Purdy
129 Pass Comp
Bet $10 to win
$21 total
OVER
22.5
+106
MATCHUP ODDS
MORE ODDS
SPREAD
TO WIN
TOTAL
San Francisco 49ers
SF
-5.5
-260
O 46.5
Indianapolis Colts
IND
+5.5
+211
U 46.5
FOX FACTS
15
BETTING
Christian McCaffrey has exceeded 104.5 rushing + receiving yards in 11 straight games as a favorite (140.0 rushing + receiving yards/game average).
BETTING
Alec Pierce has exceeded 19.5 receiving yards in 13 of his last 14 games (68.9 receiving yards/game average).
BETTING
The San Francisco 49ers are 6-0 (1.000) against the spread as a favorite over their last 6 games.
See More
PLAYER NEWS
PLAYER NEWS
Ricky Pearsall
SF #1 · WR
Pearsall (knee/ankle) isn't practicing Friday, Cam Inman of The San Jose Mercury News reports.
Alec Pierce
IND #14 · WR
Pierce (Achilles) was a full participant at Friday's practice.
Tatum Bethune
SF #48 · LB
Bethune (ankle) was a limited participant in Friday's practice, Nick Wagoner of ESPN.com reports.
STANDINGS
LEAGUE STANDINGS
AFC SOUTH
W-L-T
DIV
STRK
1
Jaguars
10-4
3-1
W5
2
Texans
9-5
4-1
W6
3
Colts
8-6
2-2
L4
4
Titans
2-12
0-5
L1
NFC WEST
W-L-T
DIV
STRK
1
Seahawks
X
12-3
3-2
W5
2
Rams
X
11-4
3-2
L1
3
49ers
10-4
4-1
W4
4
Cardinals
3-11
0-5
L6
Y
Clinched Division
X
Clinched Playoffs
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San Francisco 49ers
Indianapolis Colts
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Indianapolis, IN
27°
Wind
9 mph SSE
47°
SAT
37°
SUN
48°
MON
EVENT INFO
Lucas Oil Stadium
Indianapolis, IN
Dec 23, 2025