Chiefs vs. Titans 2025 Prediction, Odds, Picks - Dec 21

Published Dec. 19, 2025 2:43 p.m. ET

Data Skrive

The Kansas City Chiefs (6-8) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3) over the Tennessee Titans (2-12), despite the Chiefs having dropped three games in a row. The expected point total for the matchup is set at 37.5.

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Chiefs vs. Titans Odds & Betting Lines

Chiefs vs Titans Betting Information updated as of December 18, 2025, 6:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Chiefs	-3	-115	-105	37.5	-110	-110

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Chiefs vs. Titans Prediction & Pick

Pick ATS: Chiefs (-3)
Pick OU: Over (37.5)
Prediction: Chiefs 25 - Titans 18

How to Watch Kansas City vs. Tennessee

Game date: Sunday, December 21, 2025
Time: 1 p.m. ET
Venue: Nissan Stadium
Location: Nashville, Tennessee
TV: CBS
Live Boxscore: FOX Sports

Chiefs vs. Titans Recent Matchups

In their last five head-to-head contests, Tennessee has beaten Kansas City three times.
In their last five head-to-head matchups, Tennessee has racked up 125 points against Kansas City, while allowing only 111 points.

Kansas City Betting Info

Kansas City is 5-9-0 against the spread this year.
When playing as at least 3-point favorites this season, the Chiefs have an ATS record of 3-7.
Kansas City games this year have gone over the total in four out of 14 opportunities (28.6%).
When playing as moneyline favorites, the Chiefs have won 41.7% of the time (5-7).
Based on this matchup's moneyline, the Chiefs' implied win probability is 64.3%.

Chiefs Stats

Stat	Average (Total)	Rank
Pass yards	244 (3,416)	5
Rush yards	113.9 (1,595)	21
Points scored	23.4 (328)	15
Pass yards against	204 (2,856)	13
Rush yards against	99.1 (1,387)	7
Points allowed	19.1 (268)	4

Kansas City's Key Players

Offense

Kareem Hunt has collected 557 rushing yards with eight touchdowns (39.8 yards per game through 14 games). His 3.8 yards per attempt rank 39th in the league.
He has hauled in 15 passes (on 21 targets) for 122 receiving yards with one touchdown. He's averaging 8.7 receving yards and 1.1 catches per game.
Travis Kelce's 797 receiving yards this season have come from 92 targets and 67 receptions. He's averaging 56.9 receiving yards and 4.8 catches per game, with five receiving touchdowns.
Through eight games played, Rashee Rice is averaging 71.4 yards and 6.6 receptions per game to total 571 receiving yards and 53 catches. He's been targeted 78 times, and has five receiving touchdowns.
Marquise Brown has racked up 494 receiving yards and five touchdowns with 42 catches on 62 targets. He is averaging 3.2 receptions and 38.0 yards per game.

Defense

On defense, Nick Bolton has 123 tackles, 8.0 TFL, and five passes defended in 2025.
Chamarri Conner has 89 tackles, 3.0 TFL, and one sack this season. He's second on the Chiefs in tackles.
George Karlaftis III has totaled 44 tackles, 10.0 TFL, and six sacks this year.
Drue Tranquill has 2.0 sacks (fourth on the Chiefs) to go with 9.0 TFL and 79 tackles this year.

Tennessee Betting Info

Tennessee has compiled a 6-8-0 record against the spread this year.
The Titans are 6-8 ATS when underdogs by 3 points or more this year.
Tennessee games have gone over the total nine times this year.
The Titans have been underdogs in 14 games this season and won two (14.3%) of those contests.
The implied probability of a win by the Titans based on the moneyline is 40.0%.

Titans Stats

Stat	Average (Total)	Rank
Pass yards	161.9 (2,267)	31
Rush yards	88.6 (1,240)	30
Points scored	16.1 (225)	31
Pass yards against	233 (3,262)	25
Rush yards against	123.6 (1,730)	20
Points allowed	28.1 (394)	28

Tennessee's Key Players

Offense

Cameron Ward is averaging 5.6 passing yards per attempt (32nd in the NFL) and 188.4 yards per game this year, completing 59.3% of his passes on the way to 2,638 total yards, 11 touchdowns and seven interceptions through 14 games.
On the ground, Ward has added one rushing touchdown and 129 rushing yards (third on the Titans).
Tony Pollard averages 60.5 rushing yards per game through 14 games (847 total yards), while scoring five rushing touchdowns.
Pollard has added 28 receptions (2.0 per game) for 179 yards (12.8 per game), without a receiving touchdown. He's been targeted 36 times in the passing attack.
In 14 games played this season, Chimere Dike has 38 catches (2.7 receptions per game on 4.3 targets per game) for 301 yards and three receiving touchdowns.
Elic Ayomanor has 370 receiving yards and three touchdowns from 31 receptions after receiving 68 targets.

Defense

Cedric Gray has 140 tackles, 6.0 TFL, one sack, and four passes defended in 2025.
Jeffery Simmons has 55 tackles, 14.0 TFL, and nine sacks. He is fourth on the Titans in tackles.
Amani Hooker has 76 tackles, 3.0 TFL, one sack, and eight passes defended during the 2025 campaign.
Cody Barton has intercepted three passes to go with 72 tackles, 4.0 TFL, one sack, and 10 passes defended.