Chiefs vs. Titans 2025 Prediction, Odds, Picks - Dec 21

The Kansas City Chiefs (6-8) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3.5) over the Tennessee Titans (2-12), despite the Chiefs having dropped three games in a row. The matchup has an over/under of 37.5 points.

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Chiefs vs. Titans Odds & Betting Lines

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Chiefs vs. Titans Prediction & Pick

• Pick ATS: Chiefs (-3.5)
  
• Pick OU: Over (37.5)
  
• Prediction: Chiefs 25 - Titans 18

How to Watch Kansas City vs. Tennessee

• Game date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• Venue: Nissan Stadium
• Location: Nashville, Tennessee
• TV: CBS
• Live Boxscore: FOX Sports

Chiefs vs. Titans Recent Matchups

• In their past five head-to-head matchups, Tennessee has taken down Kansas City three times.
• In their last five head-to-head matchups, Tennessee has compiled 125 points versus Kansas City, while allowing only 111 points.

Kansas City Betting Info

• Against the spread, Kansas City is 5-9-0 this year.
• The Chiefs have covered the spread three times this season (3-7 ATS) when playing as at least 3.5-point favorites.
• Kansas City games this year have gone over the total in four out of 14 opportunities (28.6%).
• When playing as moneyline favorites, the Chiefs are 5-7 (winning 41.7% of the time).
• Based on this contest's moneyline, the Chiefs' implied win probability is 64.9%.

Chiefs Stats

Kansas City's Key Players

Offense

• On the ground, Kareem Hunt averages 3.8 yards per attempt (40th in the NFL) and 39.8 yards per game for 557 total rushing yards. He has recorded eight rushing touchdowns this season.
• Hunt has been targeted 21 times in the passing game and has 15 catches (1.1 per game) for 122 yards (8.7 per game) and one TD.
• Travis Kelce has caught 67 passes on 92 targets for 797 total yards and five touchdowns. He is averaging 4.8 catches and 56.9 yards per game in 14 games.
• Through eight games played, Rashee Rice is averaging 71.4 yards and 6.6 receptions per game to total 571 receiving yards and 53 catches. He's been targeted 78 times, and has five receiving touchdowns.
• Marquise Brown has racked up 494 receiving yards and five touchdowns with 42 catches on 62 targets. He's averaging 3.2 receptions and 38 yards per game.

Defense

• Over on defense, Nick Bolton has 123 tackles and eight TFL in 2025. His tackle total leads the Chiefs and is eighth in the NFL.
• Chamarri Conner has 89 tackles, three TFL, and one sack this season.
• George Karlaftis III has collected 44 tackles, 10 TFL, and six sacks this year.
• This season, Drue Tranquill has 79 tackles, nine TFL, and two sacks.

Tennessee Betting Info

• Tennessee has covered the spread six times in 14 games with a set total.
• The Titans have been underdogs by 3.5 points or more 14 times this season and are 6-8 ATS in those games.
• Games involving Tennessee have hit the over on nine occasions this season.
• The Titans have entered the game as underdogs 14 times this season and won twice.
• The implied probability of a win by the Titans based on the moneyline is 39.4%.

Titans Stats

Tennessee's Key Players

Offense

• Through 14 games played this year, Cameron Ward has racked up 2,638 passing yards, while throwing 11 touchdowns against seven interceptions and completing 59.3% of his attempts.
• On the ground, Ward has added one rushing touchdown and 129 rushing yards (third on the Titans).
• Tony Pollard averages 60.5 rushing yards per game through 14 games (847 total yards), while scoring five rushing touchdowns.
• Pollard also has 28 catches for 179 yards (eighth on the Titans). He has been targeted 36 times and averages 12.8 yards per game.
• So far this season, Chimere Dike has caught 38 passes for 301 receiving yards with three touchdowns through the air. He has been targeted 60 total times and is averaging 2.7 receptions per game through 14 games played.
• Elic Ayomanor has 370 receiving yards and three touchdowns from 31 receptions after getting 68 targets.

Defense

• Cedric Gray's 2025 output includes 140 tackles, six TFL, and one sack in 14 games. He leads the Titans and is fourth in the NFL in tackles.
• Jeffery Simmons has totaled nine sacks in addition to his 14 TFL and 55 tackles through 12 games.
• Amani Hooker has 76 tackles, three TFL, one sack, and eight passes defended in the 2025 season.
• Cody Barton's season stats include 72 tackles, four TFL, one sack, and three interceptions in 14 games. He is third on the Titans in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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