Chargers vs. Jaguars 2025 Prediction, Odds, Picks - Nov 16

Updated Nov. 16, 2025 12:43 p.m. ET

Data Skrive

The Los Angeles Chargers (7-3) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3) over the Jacksonville Jaguars (5-4). The Chargers have taken three games in a row. The predicted point total for the matchup is 43.5.

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Chargers vs. Jaguars Odds & Betting Lines

Chargers vs Jaguars Betting Information updated as of November 16, 2025, 12:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Chargers	-3	-105	-115	43.5	-110	-110

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Chargers vs. Jaguars Prediction & Pick

Pick ATS: Jaguars (+3)
Pick OU: Over (43.5)
Prediction: Jaguars 24 - Chargers 22

How to Watch Los Angeles vs. Jacksonville

Game date: Sunday, November 16, 2025
Time: 1 p.m. ET
Venue: EverBank Stadium
Location: Jacksonville, Florida
TV: CBS
Live Boxscore: FOX Sports

Chargers vs. Jaguars Recent Matchups

Over their last four meetings, Jacksonville has totaled three wins against Los Angeles.
Jacksonville has been outpaced by 3 points in its last four tilts versus Los Angeles.

Los Angeles Betting Info

Los Angeles has played 10 games, posting five wins against the spread.
The Chargers are 3-3 ATS this season when playing as at least 3-point favorites.
Los Angeles games this year have gone over the total in five out of 10 opportunities (50%).
When playing as the moneyline favorite, the Chargers are 6-3, winning 66.7% of the time.
Looking at this game's moneyline, the Chargers' implied win probability is 60.8%.

Chargers Stats

Stat	Average (Total)	Rank
Pass yards	245.4 (2,454)	7
Rush yards	123.1 (1,231)	10
Points scored	24.0 (240)	8
Pass yards against	174.2 (1,742)	5
Rush yards against	106.0 (1,060)	13
Points allowed	20.3 (203)	8

Los Angeles' Key Players

Offense

Justin Herbert ranks third in the NFL with 2,610 passing yards through 10 games this year, averaging 261 per game with a 67% completion percentage and 19 touchdowns (fourth in the NFL) against eight interceptions.
He has also rushed for 324 yards (second on the Chargers) and added one touchdown on the ground, while averaging 32.4 rushing yards per game.
Ladd McConkey has 51 receptions for 631 yards and four TDs. In 10 games, he is averaging 5.1 catches and 63.1 yards per game.
In eight games played, Quentin Johnston is averaging 62.8 yards and 4.6 receptions per game on the way to 502 receiving yards and 37 catches. He's been targeted 63 times, and has six receiving touchdowns (fourth in the NFL).
Keenan Allen averages 5.2 receptions and 53.9 yards per game, and has 539 total receiving yards and 52 catches. He's gotten 80 total targets, and has caught four touchdown passes.

Defense

On the defensive side for the Chargers, Tuli Tuipulotu has put up 25 tackles, 11 TFL, and eight sacks in 2025.
Daiyan Henley has three sacks (fifth on the Chargers) to go with four TFL, 65 tackles, and one interception.
Derwin James has recorded one interception and added 60 tackles, five TFL, 1.5 sacks, and three passes defended.
So far this season, Odafe Oweh has 22 tackles, five TFL, and four sacks.

Jacksonville Betting Info

Jacksonville has covered the spread four times this season (4-5-0).
This year, the Jaguars have two against the spread wins in four games as an underdog of 3 points or more.
Jacksonville games have gone over the total five times this year.
This season, the Jaguars have won two out of the five games in which they've been the underdog.
The Jaguars have a 43.5% chance to win this game based on the implied probability of the moneyline.

Jaguars Stats

Stat	Average (Total)	Rank
Pass yards	204.6 (1,841)	19
Rush yards	120.3 (1,083)	14
Points scored	22.8 (205)	23
Pass yards against	252.9 (2,276)	28
Rush yards against	91.7 (825)	5
Points allowed	24.4 (220)	20

Jacksonville's Key Players

Offense

Trevor Lawrence has passed for 1,998 yards this year, with 10 touchdowns and seven interceptions. He is completing 59.5% of his attempts while averaging 222 yards per game and 6.3 per attempt.
He's added 172 yards on the ground (second on the Jaguars), while scoring four rushing touchdowns. He's averaging 19.1 yards per game and 3.9 per attempt.
Travis Etienne has scored three rushing touchdowns, while totaling 656 rushing yards (4.9 per attempt and 72.9 per game).
Etienne has also picked up 130 receiving yards (14.4 per game) on 21 catches (2.3 per game). He's been targeted 31 times and has caught one touchdown pass.
Parker Washington has put up 330 receiving yards and two touchdowns on 28 receptions, while being targeted 51 times on the season.
Brian Thomas has 420 receiving yards and one touchdown from 30 receptions after getting 60 targets.

Defense

Foyesade Oluokun has intercepted one pass in addition to 75 tackles, four TFL, one sack, and six passes defended in 2025.
Andrew Wingard has 54 tackles and one interception.
Devin Lloyd has recorded two TFL, 30 tackles, and four interceptions in the 2025 season.
Jourdan Lewis has registered four TFL, 30 tackles, and two interceptions over eight games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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