Cardinals vs. Titans 2025 Prediction, Odds, Picks - Oct 5

The Tennessee Titans (0-4) will be aiming to snap a four-game losing run against the Arizona Cardinals (2-2). The Cardinals are solid favorites, expected to win by at least a touchdown (currently -7.5). The expected point total for the matchup is 41.5.

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Cardinals vs. Titans Odds & Betting Lines

Cardinals vs. Titans Prediction & Pick

• Pick ATS: Cardinals (-7.5)
  
• Pick OU: Under (41.5)
  
• Prediction: Cardinals 30 - Titans 11

How to Watch Arizona vs. Tennessee

• Game date: Sunday, October 5, 2025
• Time: 4:05 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: CBS
• Live Boxscore: FOX Sports

Cardinals vs. Titans Recent Matchups

• Over their last two meetings, Arizona has put up two wins against Tennessee.
• Over their last two head-to-head matchups, Arizona has scored 50 points, while Tennessee has accumulated 20.

Arizona Betting Info

• Arizona has covered the spread two times in 2025.
• Arizona games this year have gone over the total in one out of four opportunities (25%).
• The Cardinals have been moneyline favorites in two other games this season, and they won both.
• Based on this matchup's moneyline, the Cardinals' implied win probability is 81.0%.

Cardinals Stats

Arizona's Key Players

Offense

• Kyler Murray has 742 passing yards, six touchdowns and three interceptions this year. He has completed 66.9% of his attempts, averaging 185.5 yards per game and 5.7 per attempt.
• He has added 148 rushing yards (37 per game) without a touchdown on the ground.
• Marvin Harrison Jr.'s 208 receiving yards this season have come from 27 targets and 16 receptions. He's averaging 52 receiving yards and four catches per game, with two receiving touchdowns.
• In the passing attack, Trey McBride, has totaled 234 receiving yards and one touchdown after grabbing 24 balls (ninth in the NFL) on 35 targets. Per game, he's averaging 58.5 yards and six receptions over four games.
• Michael Wilson has put up 36 receiving yards and one touchdown with six catches on 14 targets. He is averaging 1.5 receptions and 9 yards per game.

Defense

• On defense, Mack Wilson has two TFL and 35 tackles in 2025.
• Calais Campbell has 14 tackles, four TFL, and three sacks.
• Josh Sweat has put up eight tackles, four TFL, and three sacks this year.
• Jalen Thompson has 33 tackles and one pass defended.

Tennessee Betting Info

• Tennessee has gone 1-3-0 against the spread this year.
• The Titans have covered the spread once this year when underdogs by 7.5 points or more (in two chances).
• Tennessee games have gone over the total twice this season.
• The Titans have been listed as the underdog four times this season and have failed to win any of those games.
• The Titans have a 23.3% chance to win this game based on the implied probability of the moneyline.

Titans Stats

Tennessee's Key Players

Offense

• Tony Pollard has rushed for one touchdown this year, and has racked up 261 total rushing yards (65.3 per game and 3.8 per attempt).
• On top of his impact in the run game, Pollard has caught six passes (on nine targets) for 55 yards (fifth on the Titans). He's averaging 13.8 yards per game.
• Cameron Ward has 614 passing yards, two touchdowns and two interceptions. His completion percentage is 51.2% and he averages 153.5 yards per game and 4.9 per attempt.
• Ward also has 42 rushing yards (second on the Titans).
• This season, Elic Ayomanor has caught 12 passes for 151 receiving yards with two touchdowns in the passing game. He has been targeted 25 total times and is averaging three receptions per game through four games played.
• Calvin Ridley has been targeted 24 times, resulting in 10 catches for 141 yards and zero receiving touchdowns.

Defense

• Jeffery Simmons' 2025 output includes 14 tackles, five TFL, and two sacks in four games.
• Cedric Gray's stat sheet includes 33 tackles and one TFL.
• Cody Barton has recorded one TFL, 29 tackles, and one interception in the 2025 campaign.
• Amani Hooker's stats include 23 tackles, one TFL, one sack, and three passes defended in four games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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