49ers vs. Panthers Injury Report – Week 12, 2025

Take a look at the injury report for the San Francisco 49ers (7-4), which currently has 10 players listed (including Christian McCaffrey), as the 49ers prepare for their matchup against the Carolina Panthers (6-5) at Levi's Stadium, on Monday, Nov. 24 at 8:15 p.m. ET.

Learn more about the San Francisco 49ers vs. the Carolina Panthers on FOX Sports!

49ers vs. Panthers Game Info

• When: Monday, November 24, 2025 at 8:15 p.m. ET
• Where: Levi's Stadium in Santa Clara, California
• TV info: ESPN
• Spread Favorite: 49ers (-7.5)
• Moneyline: 49ers (-395), Panthers (+310)
• Total: 49.5 points
• Live Boxscore: FOX Sports

49ers Injuries

Eddy Pineiro | K (Out)

• Injury: Hamstring
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 10 Games Played

Tatum Bethune | LB (Out)

• Injury: Ankle
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 2.0 Tackles for Loss | 64 Tackles | 0 Interceptions | 1 Pass Defended

Robert Beal | DL (Doubtful)

• Injury: Concussion
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 0.0 Tackles for Loss | 7 Tackles | 0 Interceptions | 0 Passes Defended

Luke Gifford | LB (Questionable)

• Injury: Hip
• Practice Status: Limited Participation in Practice

Dee Winters | LB

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 6.0 Tackles for Loss | 77 Tackles | 0 Interceptions | 3 Passes Defended

Trent Williams | OT

• Injury: NIR - Rest
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 4 Games Played

Curtis Robinson | LB

• Injury: Elbow
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 18 Tackles | 0 Interceptions | 0 Passes Defended

Brock Purdy | QB

• Injury: Toe
• Practice Status: Full Participation in Practice
• 2025 Passing: 99-for-67 | 786 Yards | 7 Touchdowns | 4 Interceptions

Ricky Pearsall | WR

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 32 Targets | 21 Receptions | 327 Yards | 0 Touchdowns

Christian McCaffrey | RB

• Injury: NIR - Rest
• Practice Status: Full Participation in Practice
• 2025 Rushing: 193 Attempts | 707 Yards | 6 Touchdowns
• 2025 Receiving Stats: 96 Targets | 74 Receptions | 732 Yards | 5 Touchdowns

Panthers Injuries

Cade Mays | C (Out)

• Injury: Ankle
• Practice Status: Did Not Participate In Practice
• 2025 Season Stats: 2 Games Played

Trevin Wallace | LB (Out)

• Injury: Shoulder
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 2.0 Sacks | 4.0 Tackles for Loss | 52 Tackles | 0 Interceptions | 4 Passes Defended

Christian Rozeboom | LB (Out)

• Injury: Hip
• Practice Status: Did Not Participate In Practice
• 2025 Defensive Stats: 0.0 Sacks | 5.0 Tackles for Loss | 91 Tackles | 0 Interceptions | 1 Pass Defended

Akayleb Evans | CB

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Season Stats: 5 Games Played

Lathan Ransom | S

• Injury: Hand
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 0.0 Sacks | 1.0 Tackles for Loss | 25 Tackles | 0 Interceptions | 0 Passes Defended

Xavier Legette | WR

• Injury: Hip
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 46 Targets | 24 Receptions | 264 Yards | 3 Touchdowns

Tetairoa McMillan | WR

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Receiving Stats: 89 Targets | 54 Receptions | 748 Yards | 4 Touchdowns

Bryce Young | QB

• Injury: Ankle
• Practice Status: Full Participation in Practice
• 2025 Passing: 314-for-197 | 1,962 Yards | 14 Touchdowns | 7 Interceptions

Tershawn Wharton | DT

• Injury: Knee
• Practice Status: Full Participation in Practice
• 2025 Defensive Stats: 2.0 Sacks | 2.0 Tackles for Loss | 29 Tackles | 0 Interceptions | 1 Pass Defended

49ers vs. Panthers Head-to-Head History

• In their last three head-to-head matchups, San Francisco has taken down Carolina two times.
• In their last three head-to-head matchups, San Francisco has racked up 91 points versus Carolina, while surrendering only 51 points.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Francisco 49ers

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