Yankees vs. Guardians Prediction, Odds, Picks - April 21

The Cleveland Guardians and Steven Kwan take the field at Progressive Field against Ben Rice and the New York Yankees on Monday. The favored Yankees have -125 moneyline odds to win against the underdog Guardians, who are listed at +105. New York is a 1.5-run favorite (at +135 odds). The total for the game has been listed at 8.5 runs.

Here is everything you need from a betting perspective on the Yankees-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Yankees vs. Guardians Game Information & Odds

• When: Monday, April 21, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and YES

Yankees vs. Guardians Prediction

• Score Prediction: Yankees 5, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Yankees 54%, Guardians 46%

Yankees vs. Guardians Betting Insights

• The Yankees have entered the game as favorites 18 times this season and won 13, or 72.2%, of those games.
• New York is 12-4 this season when entering a game favored by -125 or more on the moneyline.
• The Yankees have a 55.6% chance to win this game based on the implied probability of the moneyline.
• The Guardians have been chosen as underdogs in 12 games this year and have walked away with the win five times (41.7%) in those games.
• Cleveland has a win-loss record of 3-6 when favored by +105 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Guardians have a 48.8% chance of coming away with a victory in the contest.

Yankees Recent Betting Performance

• The Yankees have a 6-2 record from the eight games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Yankees combined with their opponents to hit the over on the total four times.
• The Yankees are 5-5-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge is the bat to watch in the Yankees lineup, leading the team in batting average (.390), home runs (7), and RBI (25).
• Judge is fifth in homers and first in RBI among all hitters in baseball.
• Judge carries a two-game hitting streak into this matchup. During his last five outings he is hitting .421 with a double, a home run, three walks and five RBI.
• Rice is batting .292 with three doubles, a triple, five home runs and 10 walks.
• Rice is 24th in homers and 110th in RBI among all hitters in the majors.
• Anthony Volpe is hitting .213 with five doubles, four home runs and 10 walks.
• Volpe will look to build on his two-game hitting in this matchup. In his last five games he is batting .200 with two doubles, a walk and two RBI.
• Paul Goldschmidt is hitting .361 with five doubles, a home run and six walks.
• Goldschmidt is riding a five-game hitting streak into this one. In his last five games he is batting .400 with two walks and an RBI.

Yankees Team Props

Guardians Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Guardians have a record of 3-3.
• When it comes to hitting the over, the Guardians and their opponents are 5-3-2 in their last 10 games with a total.
• The Guardians have won six of their last 10 games against the spread.

Guardians Recent Stats

Guardians Player Insights

• Kwan paces the Guardians with a .325 batting average.
• Among all batters in the big leagues, Kwan's home run total is 40th and his RBI tally is 32nd.
• Kwan carries a four-game hitting streak into this matchup. In his last five games he is batting .300 with a double, a home run, two walks and three RBI.
• Jose Ramirez is hitting .268 with four doubles, four home runs and eight walks.
• Ramirez is 40th in home runs and 110th in RBI among all major league batters this year.
• Kyle Manzardo paces the Guardians in home runs (six) and runs batted in (16).
• Gabriel Arias has three doubles, four home runs and five walks while batting .277.

Guardians Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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