Twins vs. Cardinals Prediction, Odds, Picks - March 27

Pablo Lopez and Sonny Gray are the scheduled starters when the Minnesota Twins and St. Louis Cardinals play on Opening Day at Busch Stadium, at 4:15 p.m. ET. The Cardinals are listed as -105 moneyline underdogs in this matchup against the favored Twins (-114). Minnesota (-1.5) is favored on the run line. A 7.5-run over/under is set in the game.

Check out everything you need to know from a betting perspective on the Twins-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Cardinals Game Information & Odds

• When: Thursday, March 27, 2025 at 4:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: FDSMW and MNNT

Twins vs. Cardinals Prediction

• Score Prediction: Cardinals 5, Twins 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Twins 56%, Cardinals 44%

Twins vs. Cardinals Betting Insights

• The Twins were favored on the moneyline 113 total times last season. They went 63-50 in those games.
• When it played as a moneyline favorite with odds of -114 or shorter last year, Minnesota finished with a record of 61-48 (56%).
• The implied moneyline probablility in this matchup gives the Twins a 53.3% chance to win.
• Last season, the Cardinals won 42 out of the 83 games, or 50.6%, in which they were the underdog.

Twins Player Insights

• Willi Castro finished last season with a .247 batting average while adding 12 home runs and 60 RBI.
• Carlos Correa hit .310 with an OBP of .388 and a slugging percentage of .517.
• Ryan Jeffers slugged 21 home runs and collected 64 RBI last season while batting .226.
• Byron Buxton hit .279 with an OBP of .335, and a slugging percentage of .524.

Twins Team Props

Cardinals Player Insights

• Brendan Donovan accumulated 163 hits with a batting average of .278 last season.
• Alec Burleson hit 21 home runs with 78 RBI last year.
• Masyn Winn hit .267 last season with 32 doubles, five triples, 15 home runs and 41 walks.
• Nolan Arenado hit .272 with 23 doubles, 16 home runs and 44 walks.

Cardinals Team Props

Nolan Arenado hits a walk-off single to seal Cardinals' victory over Padres

Nolan Arenado came up clutch with a walk-off single that sealed the St. Louis Cardinals' 4-3 victory over the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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St. Louis Cardinals

Minnesota Twins