Red Sox vs. Guardians Prediction, Odds, Picks - April 27

Brayan Bello gets the nod for the Boston Red Sox on Sunday against Jose Ramirez and the Cleveland Guardians. First pitch is at 1:40 p.m. ET for this final game in a three-game series. The Red Sox are -118 moneyline favorites for this matchup with the Guardians (-101). Boston is the favorite on the run line (-1.5). The game's over/under has been set at 7.5 runs.

Here is everything you need to know from a betting perspective on the Red Sox-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Red Sox vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Cleveland Guardians.

Red Sox vs. Guardians Game Information & Odds

• When: Sunday, April 27, 2025 at 1:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and NESN

Red Sox vs. Guardians Prediction

• Score Prediction: Guardians 5, Red Sox 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Red Sox 53%, Guardians 47%

Red Sox vs. Guardians Betting Insights

• The Red Sox have won 12, or 54.5%, of the 22 games they've played as favorites this season.
• Boston has a record of 11-8, a 57.9% win rate, when favored by -118 or more by sportsbooks this season.
• The moneyline for this contest implies a 54.1% chance of a victory for the Red Sox.
• The Guardians have been underdogs in 16 games this season and have come away with the win seven times (43.8%) in those contests.
• This season, Cleveland has been victorious five times in 13 chances when named as an underdog of at least -101 or longer on the moneyline.
• The Guardians have an implied victory probability of 50.2% according to the moneyline set by oddsmakers for this matchup.

Red Sox Recent Betting Performance

• The Red Sox have a 5-4 record across the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Red Sox and their opponents combined to go over the total six times (all 10 games had set totals).
• The Red Sox's record against the spread is 5-5-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Not only does Alexander David Bregman lead the Red Sox in hitting with his .324 average, he also is their foremost power hitter with five home runs and 22 RBI.
• Bregman ranks 36th in home runs and 11th in RBI among all hitters in the majors.
• Bregman carries a seven-game hitting streak into this matchup. During his last 10 games he is batting .421 with five doubles, three home runs, eight walks and 10 RBI.
• Wilyer Abreu has hit five home runs to pace his team.
• Abreu is 36th in home runs and 20th in RBI in the bigs.
• Jarren Duran has seven doubles, three triples, a home run and nine walks while hitting .256.
• Rafael Devers is batting .210 with eight doubles, three home runs and 23 walks.
• Devers brings a two-game streak with at least one hit into this one. In his last five games he is batting .188 with a double, a home run, five walks and four RBI.

Red Sox Team Props

Guardians Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Guardians have a record of 4-4.
• The Guardians and their opponents have combined to hit the over six times in their last 10 games with a total.
• The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan leads the team in batting average with a mark of .350.
• Kwan's home run total places him 55th in the big leagues, and he ranks 41st in RBI.
• Kwan brings a hitting streak of nine games into this game. During his last 10 games he is hitting .375 with three doubles, a home run, three walks and four RBI.
• Ramirez is batting .264 with four doubles, five home runs and nine walks.
• Ramirez is 36th overall in home runs and 52nd in RBI this year.
• Kyle Manzardo has been solid source of run production for the Guardians with seven long balls and 18 runs batted in.
• Gabriel Arias is hitting .272 with five doubles, four home runs and five walks.

Guardians Team Props

Red Sox vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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