Orioles vs. Guardians Prediction, Odds, Picks - April 17

The Baltimore Orioles and Adley Rutschman ready for the final of a three-game series against Jose Ramirez and the Cleveland Guardians on Thursday at Oriole Park at Camden Yards. The Orioles are listed as -128 moneyline favorites for this matchup with the Guardians (+108). Baltimore (-1.5) is the favorite on the run line. The total is 8 runs for this matchup (with -110 odds to go over and -110 odds on the under).

Check out everything you need to know from a betting perspective on the Orioles-Guardians game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Guardians vs. Orioles Highlights | MLB on FOX

Check out the best moments before the Cleveland Guardians and the Baltimore Orioles.

Orioles vs. Guardians Game Information & Odds

• When: Thursday, April 17, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and CLEG

Orioles vs. Guardians Prediction

• Score Prediction: Orioles 4, Guardians 3
• Total Prediction: Under 8 runs
• Win Probabilities: Orioles 55%, Guardians 45%

Orioles vs. Guardians Betting Insights

• The Orioles have been favorites in eight games this season and won three (37.5%) of those contests.
• Baltimore has a record of 1-2 in games when bookmakers favor them by at least -128 on the moneyline.
• The oddsmakers' moneyline implies a 56.1% chance of a victory for the Orioles.
• The Guardians have been victorious in three of the nine contests they have been chosen as underdogs in this season.
• This season, Cleveland has been victorious two times in six chances when named as an underdog of at least +108 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 48.1% chance of coming away with a victory in the contest.

Orioles Recent Betting Performance

• The Orioles have a 2-4 record from the six games they were moneyline favorites over their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Orioles and their opponents combined to hit the over five times.
• The Orioles' record against the spread is 3-7-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins paces the Orioles in home runs (four), runs batted in (17) and has a team-high batting average of .308.
• Including all MLB batters, Mullins ranks 27th in batting average, fifth in on-base percentage, and seventh in slugging.
• Mullins brings a hitting streak of two games into this game. In his last five games he is hitting .308 with two doubles, a home run, six walks and three RBI.
• Adley Rutschman is hitting .222 with two doubles, three home runs and seven walks.
• Rutschman is 55th in home runs and 149th in RBI in the majors.
• Ryan O'Hearn is hitting .302 with three doubles, two home runs and six walks.
• O'Hearn is on a three-game hitting streak entering this contest. During his last five outings he is hitting .286 with a home run, three walks and an RBI.
• Tyler O'Neill is batting .265 with three doubles, a triple, two home runs and four walks.

Orioles Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in three of their past 10 games and have gone 1-2 in those contests.
• In their last 10 games with a total, the Guardians and their opponents have combined to hit the over four times.
• Over their last 10 games, the Guardians are 4-6-0 against the spread.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan has posted a team-best batting average of .313 and leads the Guardians in runs batted in with a mark of 11.
• Among all hitters in the big leagues, Kwan is 55th in home runs and 36th in RBI.
• Jose Ramirez has put up a team-best four home runs.
• Among all MLB hitters, Ramirez is 27th in home runs and 94th in RBI.
• Kyle Manzardo paces the Guardians in home runs (four) and runs batted in (11).
• Carlos Santana has two doubles, two home runs and seven walks while batting .262.

Guardians Team Props

Guardians vs. Orioles Highlights | MLB on FOX

Check out the best moments before the Cleveland Guardians and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Baltimore Orioles

Cleveland Guardians