Giants vs. Padres Prediction, Odds, Picks - August 13

Rafael Devers and Manny Machado are the hottest hitters on the San Francisco Giants and San Diego Padres, who meet on Wednesday at Oracle Park, at 3:45 p.m. ET. The Giants are favored in this one, at -120, while the underdog Padres have +100 odds to upset. San Francisco is a 1.5-run favorite (at +175 odds). The game's total is set at 7.5 runs.

Here is everything you need to know from a betting perspective on the Giants-Padres game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Red Sox vs. Padres Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the San Diego Padres.

Giants vs. Padres Game Information & Odds

• When: Wednesday, August 13, 2025 at 3:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and SDPA

Giants vs. Padres Prediction

• Score Prediction: Giants 9, Padres 8
• Total Prediction: Over 7.5 runs
• Win Probabilities: Giants 51%, Padres 49%

Giants vs. Padres Betting Insights

• This season, the Giants have won 37 out of the 74 games, or 50%, in which they've been favored.
• San Francisco has a record of 35-34, a 50.7% win rate, when favored by -120 or more by oddsmakers this season.
• The Giants have a 54.5% chance to win this game based on the implied probability of the moneyline.
• The Padres have been victorious in 29, or 52.7%, of the 55 contests they have been chosen as underdogs in this season.
• San Diego has a win-loss record of 24-24 when favored by +100 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Padres have a 50% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants went 3-5 over the eight games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Giants and their opponents combined to hit the over on the total four times.
• The Giants have put together a 4-6-0 record against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Devers is the Giants best power hitter, crushing 23 homers this season in addition to delivering 81 RBI, both team highs.
• Of all hitters in the majors, Devers' home run total ranks him 22nd, and his RBI tally ranks him ninth.
• Devers carries a two-game hitting streak into this matchup. During his last five outings he is hitting .278 with three home runs, three walks and three RBIs.
• Jung Hoo Lee has 27 doubles, nine triples, six home runs and 38 walks while batting .256.
• Lee ranks 240th in home runs in baseball, and 119th in RBI.
• Lee carries a two-game streak with at least one hit into this contest. In his last five games he is batting .222 with .
• Willy Adames is batting .225 with 18 doubles, two triples, 18 home runs and 55 walks.
• Heliot Ramos' .268 batting average is a team-high mark.

Giants Team Props

Padres Recent Betting Performance

• Over the past 10 games, the Padres have been underdogs twice and won both contests.
• When it comes to hitting the over, the Padres and their opponents are 6-4-0 in their last 10 games with a total.
• The Padres have a record of 5-5-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Machado paces the Padres in home runs (20), runs batted in (72) and has put up a team-best batting average of .297.
• In all of MLB, Machado ranks 41st in home runs and 20th in RBI.
• Machado carries a three-game hitting streak into this matchup. In his last five games he is hitting .222 with four walks.
• Fernando Tatis Jr. is hitting .263 with 21 doubles, two triples, 17 home runs and 67 walks.
• Tatis ranks 65th in home runs and 119th in RBI among all MLB hitters this year.
• Luis Arraez is batting .290 with 23 doubles, four triples, six home runs and 25 walks.
• Xander Bogaerts is batting .268 with 26 doubles, 10 home runs and 46 walks.

Padres Team Props

Red Sox vs. Padres Highlights | MLB on FOX

Check out the best moments between the Boston Red Sox and the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco Giants

San Diego Padres