Diamondbacks vs. Giants Prediction, Odds, Picks - September 17

Geraldo Perdomo and the Arizona Diamondbacks face Jung Hoo Lee and the San Francisco Giants at Chase Field on Wednesday. First pitch is at 3:40 p.m. ET. The favored Diamondbacks have -110 moneyline odds against the underdog Giants, who are listed at -109. San Francisco is the favorite on the run line (-1.5). A 9-run over/under has been set for this game.

Here is everything you need from a betting perspective on the Diamondbacks-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Giants Game Information & Odds

• When: Wednesday, September 17, 2025 at 3:40 p.m. ET
• Where: Chase Field in Phoenix, Arizona
• How to watch on TV: MLB Network, ARID, and NBCS-BA

Diamondbacks vs. Giants Prediction

• Score Prediction: Diamondbacks 6, Giants 5
• Total Prediction: Over 9 runs
• Win Probabilities: Diamondbacks 53%, Giants 47%

Diamondbacks vs. Giants Betting Insights

• The Diamondbacks have been favorites in 86 games this season and won 45 (52.3%) of those contests.
• Arizona has a record of 45-41, a 52.3% win rate, when favored by -110 or more by bookmakers this season.
• The sportsbooks' moneyline implies a 52.4% chance of a victory for the Diamondbacks.
• The Giants have been victorious in 29, or 46%, of the 63 contests they have been chosen as underdogs in this season.
• San Francisco has a mark of 28-34 in contests where sportsbooks favor it by -109 or worse on the moneyline.
• The Giants have an implied victory probability of 52.2% according to the moneyline set for this matchup.

Diamondbacks Recent Betting Performance

• The Diamondbacks played as the moneyline favorite for three of their last 10 games, and they went 2-1 in those matchups.
• In their last 10 matchups (all had set totals), the Diamondbacks combined with their opponents to hit the over on the total six times.
• The Diamondbacks' ATS record is 6-4-0 over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Perdomo paces the Diamondbacks in runs batted in (97) and has a team-best batting average of .290.
• Of all hitters in baseball, Perdomo's home run total places him 81st, and his RBI tally puts him 13th.
• Perdomo carries a seven-game hitting streak into this matchup. In his last 10 games he is batting .333 with two doubles, a triple, two home runs, nine walks and seven RBIs.
• Corbin Carroll has shown off his power as he leads his team with 30 home runs.
• Carroll ranks 16th in home runs and 52nd in RBI in the major leagues.
• Carroll enters this game looking for his fourth game in a row with a hit. In his last five games he is batting .368 with a double, five walks and three RBIs.
• Ketel Marte has 24 doubles, 25 home runs and 63 walks while hitting .278.
• Gabriel Moreno is hitting .288 with 12 doubles, a triple, nine home runs and 22 walks.

Diamondbacks Team Props

Giants Recent Betting Performance

• The Giants have played as underdogs in five of their past 10 games and have gone 1-4 in those contests.
• When it comes to hitting the over, the Giants and their opponents are 5-4-1 in their last 10 games with a total.
• The Giants have a record of 5-5-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers leads the Giants with 31 long balls and runs batted in, driving in 102.
• Among all batters in the majors, Devers' home run total ranks 12th and his RBI tally is ninth.
• Lee's .262 batting average paces his team.
• Lee is currently 236th in homers and 144th in RBI in the major leagues.
• Willy Adames has 20 doubles, two triples, 28 home runs and 72 walks while batting .229.
• Matt Chapman is batting .237 with 20 doubles, two triples, 21 home runs and 66 walks.

Giants Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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